Neuropeptide Y inhibits excitatory enteric neurons supplying the circular muscle of the guinea pig small intestine

P. Holzer, I. Th Lippe, L. Barthó, A. Saria

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The effect of neuropeptide Y on the motor activity of the circular and longitudinal muscle of the guinea pig small intestine was investigated. Neuropeptide Y (0.3-30 nM) inhibited, in a concentration-dependent manner, the ascending enteric reflex contraction of the circular muscle; both the cholinergic and noncholinergic component of the ascending enteric reflex were suppressed. Neuropeptide Y also blocked nerve-mediated phasic contractions of the circular muscle, induced by dimethylphenylpiperazinium or ceruletide, and abolished the peristaltic movements of the small intestine. Nerve-mediated cholinergic and noncholinergic contractions of the longitudinal muscle, induced by electrical field stimulation, were only slightly depressed by neuropeptide Y. Further analysis showed that neuropeptide Y did not act directly on intestinal muscle but interrupted excitatory pathways of the enteric nervous sytem. The effect of neuropeptide Y did not involve activation of α-adrenoceptors, opioid receptors, or P1 purinoceptors or the release of endogenous factors stimulating these receptors. These findings suggest a possible physiologic role of neuropepfide Y as a nonnoradrenergic inhibitory transmitter involved in the enteric nervous control of intestinal circular muscle activity.

Original languageEnglish
Pages (from-to)1944-1950
Number of pages7
JournalGastroenterology
Volume92
Issue number6
Publication statusPublished - 1987

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Neuropeptide Y
Small Intestine
Guinea Pigs
Neurons
Muscles
Muscle Contraction
Cholinergic Agents
Reflex
Dimethylphenylpiperazinium Iodide
Ceruletide
Purinergic P1 Receptors
Opioid Receptors
Adrenergic Receptors
Electric Stimulation
Motor Activity

ASJC Scopus subject areas

  • Gastroenterology

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Neuropeptide Y inhibits excitatory enteric neurons supplying the circular muscle of the guinea pig small intestine. / Holzer, P.; Lippe, I. Th; Barthó, L.; Saria, A.

In: Gastroenterology, Vol. 92, No. 6, 1987, p. 1944-1950.

Research output: Contribution to journalArticle

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AB - The effect of neuropeptide Y on the motor activity of the circular and longitudinal muscle of the guinea pig small intestine was investigated. Neuropeptide Y (0.3-30 nM) inhibited, in a concentration-dependent manner, the ascending enteric reflex contraction of the circular muscle; both the cholinergic and noncholinergic component of the ascending enteric reflex were suppressed. Neuropeptide Y also blocked nerve-mediated phasic contractions of the circular muscle, induced by dimethylphenylpiperazinium or ceruletide, and abolished the peristaltic movements of the small intestine. Nerve-mediated cholinergic and noncholinergic contractions of the longitudinal muscle, induced by electrical field stimulation, were only slightly depressed by neuropeptide Y. Further analysis showed that neuropeptide Y did not act directly on intestinal muscle but interrupted excitatory pathways of the enteric nervous sytem. The effect of neuropeptide Y did not involve activation of α-adrenoceptors, opioid receptors, or P1 purinoceptors or the release of endogenous factors stimulating these receptors. These findings suggest a possible physiologic role of neuropepfide Y as a nonnoradrenergic inhibitory transmitter involved in the enteric nervous control of intestinal circular muscle activity.

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