Neuropeptide Y-containing interneurons in the hippocampus receive synaptic input from median raphe and Gabaergic septal afferents

R. Miettinen, T. Freund

Research output: Contribution to journalArticle

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Abstract

Neuropeptide Y has been extensively studied in the central nervous system due to a possible involvement of neuropeptide Y-containing neurons in cognitive functions. In the hippocampus neuropeptide Y is present in a subpopulation of nonpyramidal cells, which control the firing of hippocampal output neurons. In the present study we examined whether septohippocampal and raphe-hippocampal afferents - known to have a powerful effect on hippocampal electrical activity patterns - innervate neuropeptide Y-containing neurons in the hippocampal formation of the rat. Using a combination of pre- and postembedding immunostaining and tracing with Phaseolus vulgaris leucoagglutinin (PHAL) we showed that GABAergic afferents arising from the medial septal area extensively innervate neuropeptide Y-containing neurons. Afferents of median raphe origin, most of which are thought to be serotonergic, were also found to make multiple synaptic contacts with these cells. Thus, the neuropeptide Y-containing subpopulation of interneurons - which innervate distal dendrites of principal cells - are also among those through which different subcortical nuclei modulate information processing in the hippocampal formation.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
JournalNeuropeptides
Volume22
Issue number3
DOIs
Publication statusPublished - 1992

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Neuropeptide Y
Interneurons
Hippocampus
Neurons
Septum of Brain
Neurology
Dendrites
Automatic Data Processing
Cognition
Rats
Central Nervous System
Cells

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

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Neuropeptide Y-containing interneurons in the hippocampus receive synaptic input from median raphe and Gabaergic septal afferents. / Miettinen, R.; Freund, T.

In: Neuropeptides, Vol. 22, No. 3, 1992, p. 185-193.

Research output: Contribution to journalArticle

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