Neuropathologic changes in the olfactory bulb in Alzheimer's disease

I. Kovacs, I. Torok, J. Zombori, P. Kasa

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Abstract

1. For the first time we have described the structural localization of AChE in the different layers of the human OB. In constrast with the rat, no cholinergic structures were detected in the GL and the outer part of the EPL in the human OB. 2. No correlation was found between the AChE (and perhaps the cholinergic axon) content and the neuropathologic changes. 3. Diffuse amyloid β-protein staining was present in or near the olfactory sensory axons within the GL in the AD samples. 4. Rats may not serve as an accurate model for AD as the cholinergic fibers are more diffusely distributed in the different layers than in the human OB.

Original languageEnglish
Pages (from-to)123-126
Number of pages4
JournalNEUROBIOLOGY
Volume4
Issue number1-2
Publication statusPublished - Dec 1 1996

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kovacs, I., Torok, I., Zombori, J., & Kasa, P. (1996). Neuropathologic changes in the olfactory bulb in Alzheimer's disease. NEUROBIOLOGY, 4(1-2), 123-126.