Neurons with distinctive firing patterns, morphology and distribution in laminae V-VII of the neonatal rat lumbar spinal cord

Péter Szûcs, Francis Odeh, Karolina Szokol, M. Antal

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

It is generally accepted that neurons in the ventral spinal grey matter, a substantial proportion of which can be regarded as constituents of the spinal motor apparatus, receive and integrate synaptic inputs arising from various peripheral, spinal and supraspinal sources. Thus, a profound knowledge concerning the integrative properties of interneurons in the spinal ventral grey matter appears to be essential for a fair understanding of operational principles of spinal motor neural assemblies. Using the whole cell patch clamp configuration in a correlative physiological and morphological experimental approach, here we demonstrate that the intrinsic membrane properties of neurons vary widely in laminae V-VII of the ventral grey matter of the neonatal rat lumbar spinal cord. Based on their firing patterns in response to depolarizing current steps, we have classified the recorded neurons into four categories: 'phasic', 'repetitive', 'single' and 'slow'. Neurons with firing properties characteristic of the 'phasic', 'repetitive' and 'single' cells have previously been reported also in the superficial and deep spinal dorsal horn, but this is the first account in the literature in which 'slow' neurons have been recovered and described in the spinal cord. The physiological heterogeneity in conjunction with the morphological correlation and distribution of neurons argues that different components of motor neural assemblies in the spinal ventral grey matter possess different signal processing characteristics.

Original languageEnglish
Pages (from-to)537-544
Number of pages8
JournalEuropean Journal of Neuroscience
Volume17
Issue number3
DOIs
Publication statusPublished - Feb 2003

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Spinal Cord
Neurons
Interneurons
Membranes
Gray Matter

Keywords

  • Biocytin labelling
  • Slice preparation
  • Spinal interneurons
  • Whole cell patch clamp

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neurons with distinctive firing patterns, morphology and distribution in laminae V-VII of the neonatal rat lumbar spinal cord. / Szûcs, Péter; Odeh, Francis; Szokol, Karolina; Antal, M.

In: European Journal of Neuroscience, Vol. 17, No. 3, 02.2003, p. 537-544.

Research output: Contribution to journalArticle

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