Neuronal peptide (enkephalin) receptors in the ear artery of the rabbit

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Methionine-enkephalin methylester (MEM) and leucine-enkephalin (LE) inhibit the vasoconstrictor responses of the rabbit ear artery to nerve stimulation by acting on a specific neuronal peptide (enkephalin)-receptor insensitive to opiate agonists. The tetrapeptide: H-Tyr-Gly-Phe-Leu-OCH3 is ineffective. This is the first instance of enkephalins acting in an organ devoid of receptors. In a new test for the analysis of opiate receptors, MEM (ID50 = 6.9 × 10-9 M) was a potent inhibitor of transmission. The presence was shown of opiate receptors in the brain which were insensitive to high i.v. or intraventricular doses of enkephalins. It is concluded that enkephalins are not natural ligands to the opiate receptors, but that some of the receptors confuse these structures because of similar characteristics which determine the binding of both opiates and peptides.

Original languageEnglish
Pages (from-to)403-407
Number of pages5
JournalEuropean Journal of Pharmacology
Volume39
Issue number2
DOIs
Publication statusPublished - 1976

Fingerprint

Peptide Receptors
Opioid Receptors
Ear
Enkephalins
Arteries
Rabbits
Methionine Enkephalin
Opiate Alkaloids
Leucine Enkephalin
Opioid Peptides
Vasoconstrictor Agents
Ligands
Brain

Keywords

  • Enkephalin receptors
  • H-Tyr-Gly-Phe-Leu-OCH
  • Leucine-enkephalin
  • Methionine-enkephalin methylester
  • Opiate receptors
  • Rabbit ear artery

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Neuronal peptide (enkephalin) receptors in the ear artery of the rabbit. / Knoll, Joseph.

In: European Journal of Pharmacology, Vol. 39, No. 2, 1976, p. 403-407.

Research output: Contribution to journalArticle

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