Neuronal coding of auditory sensorimotor gating in medial prefrontal cortex

Attila Tóth, Zoltán Petykó, Rita Gálosi, I. Szabó, Kázmér Karádi, Ádám Feldmann, László Péczely, Veronika Kállai, Zoltán Karádi, L. Lénárd

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The medial prefrontal cortex (mPFC) is thought to be an essential brain region for sensorimotor gating. The exact neuronal mechanisms, however, have not been extensively investigated yet by delicate single unit recording methods Prepulse inhibition (PPI) of the startle response is a broadly used important tool to investigate the inhibitory processes of sensorimotor gating. The present study was designed to examine the neuronal mechanisms of sensorimotor gating in the mPFC in freely moving rats. In these experiments, the animals were subjected to both pulse alone and prepulse + pulse stimulations. Head acceleration and the neuronal activity of the mPFC were simultaneously recorded. To adequately measure the startle reflex, a new headstage with 3D-accelerometer was created. The duration of head acceleration was longer in pulse alone trials than in prepulse + pulse trial conditions, and the amplitude of head movements was significantly larger during the pulse alone than during the prepulse + pulse situations. Single unit activities in the mPFC were recorded by means of chronically implanted tetrodes during acoustic stimulation evoked startle response and PPI. High proportion of medial prefrontal cortical neurons responded to these stimulations by characteristic firing patterns: short duration equal and unequal excitatory, medium duration excitatory, and long duration excitatory and inhibitory responses were recorded. The present findings, first time in the literature, demonstrated the startle and PPI elicited neuronal activity changes of the mPFC, and thus, provided evidence for a key role of this limbic forebrain area in sensorimotor gating process.

Original languageEnglish
Pages (from-to)200-208
Number of pages9
JournalBehavioural Brain Research
Volume326
DOIs
Publication statusPublished - May 30 2017

Fingerprint

Sensory Gating
Prefrontal Cortex
Startle Reflex
Head
Acoustic Stimulation
Head Movements
Prosencephalon
Neurons
Brain
Prepulse Inhibition

Keywords

  • 3D head acceleration
  • Medial prefrontal cortex
  • Prepulse inhibition
  • Sensorimotor gating
  • Startle

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Neuronal coding of auditory sensorimotor gating in medial prefrontal cortex. / Tóth, Attila; Petykó, Zoltán; Gálosi, Rita; Szabó, I.; Karádi, Kázmér; Feldmann, Ádám; Péczely, László; Kállai, Veronika; Karádi, Zoltán; Lénárd, L.

In: Behavioural Brain Research, Vol. 326, 30.05.2017, p. 200-208.

Research output: Contribution to journalArticle

Tóth, A, Petykó, Z, Gálosi, R, Szabó, I, Karádi, K, Feldmann, Á, Péczely, L, Kállai, V, Karádi, Z & Lénárd, L 2017, 'Neuronal coding of auditory sensorimotor gating in medial prefrontal cortex', Behavioural Brain Research, vol. 326, pp. 200-208. https://doi.org/10.1016/j.bbr.2017.03.004
Tóth, Attila ; Petykó, Zoltán ; Gálosi, Rita ; Szabó, I. ; Karádi, Kázmér ; Feldmann, Ádám ; Péczely, László ; Kállai, Veronika ; Karádi, Zoltán ; Lénárd, L. / Neuronal coding of auditory sensorimotor gating in medial prefrontal cortex. In: Behavioural Brain Research. 2017 ; Vol. 326. pp. 200-208.
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