Neuromyelitis optica

újdonságok a Devic-betegség patogenezisében, diagnosztikájában és terápiájában

Translated title of the contribution: Neuromyelitis optica spectrum: Novel concept of pathogenesis, diagnosis and treatment of Devic's disease

Péter Csécsei, Anita Trauninger, S. Komoly, Zsolt Illés

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The identification of autoantibodies generated against the brain isoform water channel aquaporin4 in the sera of patients, changed the current diagnostic guidelines and concept of neuromyelitis optica (NMO). In a number of cases, clinical manifestation is spatially limited to myelitis or relapsing optic neuritis creating a diverse. NMO spectrum. Since prevention of relapses provides the only possibility to reduce permanent disability, early diagnosis and treatment is mandatory. In the present study, we discuss the potential role of neuroimaging and laboratory tests in differentiating the NMO spectrum from other diseases, as well as the diagnostic procedures and therapeutic options. We also present clinical cases, to provide examples of different clinical settings, diagnostic procedures and therapeutic decisions.

Original languageHungarian
Pages (from-to)2101-2109
Number of pages9
JournalOrvosi Hetilap
Volume150
Issue number46
DOIs
Publication statusPublished - 2009

Fingerprint

Neuromyelitis Optica
Myelitis
Optic Neuritis
Aquaporins
Secondary Prevention
Neuroimaging
Autoantibodies
Early Diagnosis
Protein Isoforms
Therapeutics
Guidelines
Brain
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neuromyelitis optica : újdonságok a Devic-betegség patogenezisében, diagnosztikájában és terápiájában. / Csécsei, Péter; Trauninger, Anita; Komoly, S.; Illés, Zsolt.

In: Orvosi Hetilap, Vol. 150, No. 46, 2009, p. 2101-2109.

Research output: Contribution to journalArticle

Csécsei, Péter ; Trauninger, Anita ; Komoly, S. ; Illés, Zsolt. / Neuromyelitis optica : újdonságok a Devic-betegség patogenezisében, diagnosztikájában és terápiájában. In: Orvosi Hetilap. 2009 ; Vol. 150, No. 46. pp. 2101-2109.
@article{bf171e12134e4b9383a45dc0e39c266a,
title = "Neuromyelitis optica: {\'u}jdons{\'a}gok a Devic-betegs{\'e}g patogenezis{\'e}ben, diagnosztik{\'a}j{\'a}ban {\'e}s ter{\'a}pi{\'a}j{\'a}ban",
abstract = "The identification of autoantibodies generated against the brain isoform water channel aquaporin4 in the sera of patients, changed the current diagnostic guidelines and concept of neuromyelitis optica (NMO). In a number of cases, clinical manifestation is spatially limited to myelitis or relapsing optic neuritis creating a diverse. NMO spectrum. Since prevention of relapses provides the only possibility to reduce permanent disability, early diagnosis and treatment is mandatory. In the present study, we discuss the potential role of neuroimaging and laboratory tests in differentiating the NMO spectrum from other diseases, as well as the diagnostic procedures and therapeutic options. We also present clinical cases, to provide examples of different clinical settings, diagnostic procedures and therapeutic decisions.",
keywords = "Aquaporin, Devic's disease, Neuromyelitis optica, Optic neuritis, Transverse myelitis",
author = "P{\'e}ter Cs{\'e}csei and Anita Trauninger and S. Komoly and Zsolt Ill{\'e}s",
year = "2009",
doi = "10.1556/OH.2009.28724",
language = "Hungarian",
volume = "150",
pages = "2101--2109",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "46",

}

TY - JOUR

T1 - Neuromyelitis optica

T2 - újdonságok a Devic-betegség patogenezisében, diagnosztikájában és terápiájában

AU - Csécsei, Péter

AU - Trauninger, Anita

AU - Komoly, S.

AU - Illés, Zsolt

PY - 2009

Y1 - 2009

N2 - The identification of autoantibodies generated against the brain isoform water channel aquaporin4 in the sera of patients, changed the current diagnostic guidelines and concept of neuromyelitis optica (NMO). In a number of cases, clinical manifestation is spatially limited to myelitis or relapsing optic neuritis creating a diverse. NMO spectrum. Since prevention of relapses provides the only possibility to reduce permanent disability, early diagnosis and treatment is mandatory. In the present study, we discuss the potential role of neuroimaging and laboratory tests in differentiating the NMO spectrum from other diseases, as well as the diagnostic procedures and therapeutic options. We also present clinical cases, to provide examples of different clinical settings, diagnostic procedures and therapeutic decisions.

AB - The identification of autoantibodies generated against the brain isoform water channel aquaporin4 in the sera of patients, changed the current diagnostic guidelines and concept of neuromyelitis optica (NMO). In a number of cases, clinical manifestation is spatially limited to myelitis or relapsing optic neuritis creating a diverse. NMO spectrum. Since prevention of relapses provides the only possibility to reduce permanent disability, early diagnosis and treatment is mandatory. In the present study, we discuss the potential role of neuroimaging and laboratory tests in differentiating the NMO spectrum from other diseases, as well as the diagnostic procedures and therapeutic options. We also present clinical cases, to provide examples of different clinical settings, diagnostic procedures and therapeutic decisions.

KW - Aquaporin

KW - Devic's disease

KW - Neuromyelitis optica

KW - Optic neuritis

KW - Transverse myelitis

UR - http://www.scopus.com/inward/record.url?scp=70449586752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70449586752&partnerID=8YFLogxK

U2 - 10.1556/OH.2009.28724

DO - 10.1556/OH.2009.28724

M3 - Article

VL - 150

SP - 2101

EP - 2109

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 46

ER -