Neuromorphological background of cannabis addiction

T. Wenger, Gabriella Moldrich, S. Fürst

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The expression of central cannabinoid (CB1) receptors in tyrosine hydroxylase (TH) containing neurones was demonstrated. Co-localisation was present in different brain areas responsible for reward-related mechanisms. The immunohistochemical investigations have shown that co-localisation is present in parts of mesolimbic-mesocortical dopaminergic system like nucleus accumbens (Nacb), ventral tegmental area (VTA), in the striatum, pyriform cortex, respectively. The results suggest a functional role of CB1 receptors in cannabis addiction by acting directly on reward-related structures.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalBrain Research Bulletin
Volume61
Issue number2
DOIs
Publication statusPublished - Jul 15 2003

Fingerprint

Cannabinoid Receptor CB1
Cannabis
Reward
Ventral Tegmental Area
Nucleus Accumbens
Tyrosine 3-Monooxygenase
Neurons
Brain
Piriform Cortex

Keywords

  • Central cannabinoid receptor
  • Dopamine
  • Immunohistochemistry
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuromorphological background of cannabis addiction. / Wenger, T.; Moldrich, Gabriella; Fürst, S.

In: Brain Research Bulletin, Vol. 61, No. 2, 15.07.2003, p. 125-128.

Research output: Contribution to journalArticle

Wenger, T. ; Moldrich, Gabriella ; Fürst, S. / Neuromorphological background of cannabis addiction. In: Brain Research Bulletin. 2003 ; Vol. 61, No. 2. pp. 125-128.
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