Neuromorphological background of cannabis addiction

Tibor Wenger, Gabriella Moldrich, Susanna Furst

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The expression of central cannabinoid (CB1) receptors in tyrosine hydroxylase (TH) containing neurones was demonstrated. Co-localisation was present in different brain areas responsible for reward-related mechanisms. The immunohistochemical investigations have shown that co-localisation is present in parts of mesolimbic-mesocortical dopaminergic system like nucleus accumbens (Nacb), ventral tegmental area (VTA), in the striatum, pyriform cortex, respectively. The results suggest a functional role of CB1 receptors in cannabis addiction by acting directly on reward-related structures.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalBrain Research Bulletin
Volume61
Issue number2
DOIs
Publication statusPublished - Jul 15 2003

Keywords

  • Central cannabinoid receptor
  • Dopamine
  • Immunohistochemistry
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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