Neuroinflammatory reactions in experimental gastric ulcer

Target for mucosal protection

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effect of different opioids receptor agonists - morphine, DAGO (μ-agonists), DADLE, DPDPE and deltorphin II (δ-agonists)- on gastric mucosal damage induced by either acidified ethanol or acidified aspirin was studied following subcutaneous (sc) administration of these agonists. The results indicate that both μ and δ receptors are involved in gastroprotection. Morphine, DAGO and DADLE, injected intracerebroventricularly, were also effective in both ulcer models. This suggests that gastric cytoprotection can be induced also be central action, since gastric acid secretion is not involved in the pathomechanism of mucosal damage induced by acidified ethanol. Interaction between the opioids and α2-adrenoceptors in gastroprotection is suggested by the findings that the gastroprotective effect of clonidine (0.09 μmol/kg orally) was antagonized by opioid antagonists. As both naloxone (1.38 μmol/kg sc) and naltrindole (12 μmol/kg sc) exerted antagonist effects, both μ and δ receptors are likely to be involved in presynaptic α2-receptor-mediated gastroprotection.

Original languageEnglish
Pages (from-to)383-395
Number of pages13
JournalInflammopharmacology
Volume5
Issue number4
Publication statusPublished - 1997

Fingerprint

Leucine-2-Alanine Enkephalin
Ala(2)-MePhe(4)-Gly(5)-enkephalin
naltrindole
Stomach Ulcer
Morphine
Stomach
Ethanol
D-Penicillamine (2,5)-Enkephalin
Presynaptic Receptors
Cytoprotection
Narcotic Antagonists
Gastric Acid
Clonidine
Opioid Receptors
Naloxone
Adrenergic Receptors
Opioid Analgesics
Aspirin
Ulcer

Keywords

  • α-Agonists
  • Gastric mucosal defence
  • Opioids

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Neuroinflammatory reactions in experimental gastric ulcer : Target for mucosal protection. / Gyires, K.

In: Inflammopharmacology, Vol. 5, No. 4, 1997, p. 383-395.

Research output: Contribution to journalArticle

@article{6a9b9bc43cb14c47bd606f996f5c621f,
title = "Neuroinflammatory reactions in experimental gastric ulcer: Target for mucosal protection",
abstract = "The effect of different opioids receptor agonists - morphine, DAGO (μ-agonists), DADLE, DPDPE and deltorphin II (δ-agonists)- on gastric mucosal damage induced by either acidified ethanol or acidified aspirin was studied following subcutaneous (sc) administration of these agonists. The results indicate that both μ and δ receptors are involved in gastroprotection. Morphine, DAGO and DADLE, injected intracerebroventricularly, were also effective in both ulcer models. This suggests that gastric cytoprotection can be induced also be central action, since gastric acid secretion is not involved in the pathomechanism of mucosal damage induced by acidified ethanol. Interaction between the opioids and α2-adrenoceptors in gastroprotection is suggested by the findings that the gastroprotective effect of clonidine (0.09 μmol/kg orally) was antagonized by opioid antagonists. As both naloxone (1.38 μmol/kg sc) and naltrindole (12 μmol/kg sc) exerted antagonist effects, both μ and δ receptors are likely to be involved in presynaptic α2-receptor-mediated gastroprotection.",
keywords = "α-Agonists, Gastric mucosal defence, Opioids",
author = "K. Gyires",
year = "1997",
language = "English",
volume = "5",
pages = "383--395",
journal = "Inflammopharmacology",
issn = "0925-4692",
publisher = "Birkhauser Verlag Basel",
number = "4",

}

TY - JOUR

T1 - Neuroinflammatory reactions in experimental gastric ulcer

T2 - Target for mucosal protection

AU - Gyires, K.

PY - 1997

Y1 - 1997

N2 - The effect of different opioids receptor agonists - morphine, DAGO (μ-agonists), DADLE, DPDPE and deltorphin II (δ-agonists)- on gastric mucosal damage induced by either acidified ethanol or acidified aspirin was studied following subcutaneous (sc) administration of these agonists. The results indicate that both μ and δ receptors are involved in gastroprotection. Morphine, DAGO and DADLE, injected intracerebroventricularly, were also effective in both ulcer models. This suggests that gastric cytoprotection can be induced also be central action, since gastric acid secretion is not involved in the pathomechanism of mucosal damage induced by acidified ethanol. Interaction between the opioids and α2-adrenoceptors in gastroprotection is suggested by the findings that the gastroprotective effect of clonidine (0.09 μmol/kg orally) was antagonized by opioid antagonists. As both naloxone (1.38 μmol/kg sc) and naltrindole (12 μmol/kg sc) exerted antagonist effects, both μ and δ receptors are likely to be involved in presynaptic α2-receptor-mediated gastroprotection.

AB - The effect of different opioids receptor agonists - morphine, DAGO (μ-agonists), DADLE, DPDPE and deltorphin II (δ-agonists)- on gastric mucosal damage induced by either acidified ethanol or acidified aspirin was studied following subcutaneous (sc) administration of these agonists. The results indicate that both μ and δ receptors are involved in gastroprotection. Morphine, DAGO and DADLE, injected intracerebroventricularly, were also effective in both ulcer models. This suggests that gastric cytoprotection can be induced also be central action, since gastric acid secretion is not involved in the pathomechanism of mucosal damage induced by acidified ethanol. Interaction between the opioids and α2-adrenoceptors in gastroprotection is suggested by the findings that the gastroprotective effect of clonidine (0.09 μmol/kg orally) was antagonized by opioid antagonists. As both naloxone (1.38 μmol/kg sc) and naltrindole (12 μmol/kg sc) exerted antagonist effects, both μ and δ receptors are likely to be involved in presynaptic α2-receptor-mediated gastroprotection.

KW - α-Agonists

KW - Gastric mucosal defence

KW - Opioids

UR - http://www.scopus.com/inward/record.url?scp=0030772948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030772948&partnerID=8YFLogxK

M3 - Article

VL - 5

SP - 383

EP - 395

JO - Inflammopharmacology

JF - Inflammopharmacology

SN - 0925-4692

IS - 4

ER -