Neuroimmune link in the mucosa of chronic gastritis with Helicobacter pylori infection

G. Sipos, K. Altdorfer, É Pongor, L. P. Chen, E. Fehér

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

It is suggested that different neuropeptides regulate gastric mucosal integrity and participate in the development of chronic gastritis. The aim of this study was to examine the roles and changes of immunoreactive (IR) nerves and immunocompetent cells in human gastritis. Immunohistochemical, immunocytochemical, and confocal laser microscopic methods were used. All investigated nerve fibers were found in different quantities in the mucosa of both control and gastritis samples. The number of SP, NPY, and VIP IR nerve fibers increased significantly (P <0.05) in gastritis. No IR immunocompetent cells (lymphocytes, plasma cells, mast cells) were found in the control, however, some showed NPY (16.8%) and SP (9.4%) immunoreactivity in chronic gastritis. The distance between nerve fibers and immunocompetent cells was 200 nm to 1 μm. In conclusion, the increased number of SP, NPY, and VIP IR nerves and IR immunocytes suggests that they participate in development of neurogenic inflammation, repairing processes of chronic gastritis.

Original languageEnglish
Pages (from-to)1810-1817
Number of pages8
JournalDigestive Diseases and Sciences
Volume51
Issue number10
DOIs
Publication statusPublished - Oct 2006

Fingerprint

Helicobacter Infections
Gastritis
Helicobacter pylori
Mucous Membrane
Nerve Fibers
Neurogenic Inflammation
Plasma Cells
Neuropeptides
Mast Cells
Stomach
Lasers
Lymphocytes
Neurons

Keywords

  • Gastritis
  • Immunohistochemistry
  • Neuroimmunomodulation
  • Neuropeptides

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Neuroimmune link in the mucosa of chronic gastritis with Helicobacter pylori infection. / Sipos, G.; Altdorfer, K.; Pongor, É; Chen, L. P.; Fehér, E.

In: Digestive Diseases and Sciences, Vol. 51, No. 10, 10.2006, p. 1810-1817.

Research output: Contribution to journalArticle

Sipos, G. ; Altdorfer, K. ; Pongor, É ; Chen, L. P. ; Fehér, E. / Neuroimmune link in the mucosa of chronic gastritis with Helicobacter pylori infection. In: Digestive Diseases and Sciences. 2006 ; Vol. 51, No. 10. pp. 1810-1817.
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