Neuroimmune interactions in experimental colitis: An immunoelectron microscopic study

E. Fehér, Károly Altdorfer, Gábor Bagaméri, J. Fehér

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

With its abundance of neurons and immunocytes, the gut is a potentially important site for the study of the interaction between the nervous and immune systems. In this electron microscopic study we have investigated the distribution of substance P (SP)- and vasoactive intestinal polypeptide (VIP)-immunoreactive (IR) nerve terminals and the immunocytes during experimental colitis in the rat. A mild colitis was induced by a luminal enema containing trinitrobenzene sulfonic acid. The most severe inflammation was detected after 2 days and the density and the distribution of the SP- and VIP-IR nerve terminals as well as the immunocompetent cells were studied at that time. Many SP- and VIP-IR nerve terminals were observed in a very close situation to the inflammatory cells. The number of VIP-IR nerve terminals slightly increased in the inflamed area. The gap between the axolemma of the nerve terminals and immunocytes was 20-200 nm. Some lymphocytes and plasma cells were also IR for SP in the inflamed area, whereas no IR immunocytes were observed in the control and in noninflamed area from the same animal. The very close apposition of the SP- and VIP-IR nerve terminals to the inflammatory cells as well as the presence of SP-IR immunocytes in inflamed area support the suggestion that bidirectional neuroimmunomodulation exists in the colon.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalNeuroImmunoModulation
Volume9
Issue number5
DOIs
Publication statusPublished - 2001

Fingerprint

Colitis
Substance P
Vasoactive Intestinal Peptide
Neuroimmunomodulation
Trinitrobenzenes
Sulfonic Acids
Enema
Plasma Cells
Nervous System
Immune System
Colon
Lymphocytes
Electrons
Inflammation
Neurons

Keywords

  • Immunocytes
  • Neuroimmunomodulation
  • Substance P
  • Vasoactive intestinal polypeptide

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Immunology

Cite this

Neuroimmune interactions in experimental colitis : An immunoelectron microscopic study. / Fehér, E.; Altdorfer, Károly; Bagaméri, Gábor; Fehér, J.

In: NeuroImmunoModulation, Vol. 9, No. 5, 2001, p. 247-255.

Research output: Contribution to journalArticle

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