Neuroimaging and cognitive changes during déjà vu

N. Kovács, Tibor Auer, Istvan Balas, Kazmer Karadi, Katalin Zambo, Attila Schwarcz, P. Klivényi, Hennric Jokeit, Krisztina Horvath, Ferenc Nagy, J. Janszky

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: The cause or the physiological role of déjà vu (DV) in healthy people is unknown. The pathophysiology of DV-type epileptic aura is also unresolved. Here we describe a 22-year-old woman treated with deep brain stimulation (DBS) of the left internal globus pallidus for hemidystonia. At certain stimulation settings, DBS elicited reproducible episodes of DV. Methods: Neuropsychological tests and single-photon-emission computed tomography (SPECT) were performed during DBS-evoked DV and during normal DBS stimulation without DV. Results: SPECT during DBS-evoked DV revealed hyperperfusion of the right (contralateral to the electrode) hippocampus and other limbic structures. Neuropsychological examinations performed during several evoked DV episodes revealed disturbances in nonverbal memory. Conclusion: Our results confirm the role of mesiotemporal structures in the pathogenesis of DV. We hypothesize that individual neuroanatomy and disturbances in gamma oscillations or in the dopaminergic system played a role in DBS-elicited DV in our patient.

Original languageEnglish
Pages (from-to)190-196
Number of pages7
JournalEpilepsy and Behavior
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2009

Fingerprint

Deep Brain Stimulation
Neuroimaging
Single-Photon Emission-Computed Tomography
Neuroanatomy
Globus Pallidus
Neuropsychological Tests
Epilepsy
Hippocampus
Electrodes

Keywords

  • Adverse reaction
  • Aura
  • Déjà vu
  • Deep brain stimulation
  • Dystonia
  • Epilepsy
  • Magnetic resonance imaging
  • Pallidum
  • Single-photon-emission computed tomography
  • Subtraction ictal single-photon-emission computed tomography co-registered to magnetic resonance imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Neuroimaging and cognitive changes during déjà vu. / Kovács, N.; Auer, Tibor; Balas, Istvan; Karadi, Kazmer; Zambo, Katalin; Schwarcz, Attila; Klivényi, P.; Jokeit, Hennric; Horvath, Krisztina; Nagy, Ferenc; Janszky, J.

In: Epilepsy and Behavior, Vol. 14, No. 1, 01.2009, p. 190-196.

Research output: Contribution to journalArticle

Kovács, N, Auer, T, Balas, I, Karadi, K, Zambo, K, Schwarcz, A, Klivényi, P, Jokeit, H, Horvath, K, Nagy, F & Janszky, J 2009, 'Neuroimaging and cognitive changes during déjà vu', Epilepsy and Behavior, vol. 14, no. 1, pp. 190-196. https://doi.org/10.1016/j.yebeh.2008.08.017
Kovács N, Auer T, Balas I, Karadi K, Zambo K, Schwarcz A et al. Neuroimaging and cognitive changes during déjà vu. Epilepsy and Behavior. 2009 Jan;14(1):190-196. https://doi.org/10.1016/j.yebeh.2008.08.017
Kovács, N. ; Auer, Tibor ; Balas, Istvan ; Karadi, Kazmer ; Zambo, Katalin ; Schwarcz, Attila ; Klivényi, P. ; Jokeit, Hennric ; Horvath, Krisztina ; Nagy, Ferenc ; Janszky, J. / Neuroimaging and cognitive changes during déjà vu. In: Epilepsy and Behavior. 2009 ; Vol. 14, No. 1. pp. 190-196.
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