Neurohypophysial hormone secretion in hyperprolactinaemic women

F. Laczi, A. Szasz, M. Vecsernyés, J. Julesz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Prolactin (PRL) has been reported to promote antidiuresis and increase intestinal water-electrolyte absorption, whereas osmolar changes have been shown to influence PRL secretion. However, the mechanisms of action of PRL on the salt-water balance remain unclarified. The present clinical study targeted the effects of hyperprolactinaemia on the secretion of arginine-8- vasopressin (AVP), cxytocin (OXT) and cortisol. Plasma AVP and OXT were measured by radioimmunoassay, and cortisol by fluorimetry. In healthy women (21-39 y, n=6), an oral water load (OWL, 20 ml/bw) significantly suppressed the plasma levels of AVP, OXT and cortisol, and the PRL level too tended to decrease. In hyperprolactinaemic females (22-41 y, n=6, three with pituitary adenomas), water retention was registered following an OWL, together with paradoxical AVP and OXT level increases, whereas the cortisol response remained normal, and the PRL level did not change at all. Histamine (0.5 mg sc) stimulated the release of AVP, OXT and cortisol in the control and hyperprolactinaemic groups alike. These data suggest that alterations in AVP and OXT hypersecretion may contribute to the water retention in hyperprolactinaermia.

Original languageEnglish
Pages (from-to)435-437
Number of pages3
JournalNeuropeptides
Volume32
Issue number5
DOIs
Publication statusPublished - 1998

Fingerprint

Posterior Pituitary Hormones
Arginine Vasopressin
Vasopressins
Arginine
Prolactin
Hydrocortisone
Water
Plasmas
Fluorometry
Hyperprolactinemia
Saline water
Pituitary Neoplasms
Histamine
Electrolytes
Radioimmunoassay
Salts
Control Groups

ASJC Scopus subject areas

  • Endocrinology
  • Clinical Neurology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Biochemistry

Cite this

Neurohypophysial hormone secretion in hyperprolactinaemic women. / Laczi, F.; Szasz, A.; Vecsernyés, M.; Julesz, J.

In: Neuropeptides, Vol. 32, No. 5, 1998, p. 435-437.

Research output: Contribution to journalArticle

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