Neurogenic inflammation of gingivomucosal tissue in streptozotocin-diabetic rat

E. Fehér, A. Gyorffi, Á Fazekas

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Previously it was assumed that nerve fibres are involved in the neurogenic inflammation induced by mechanical or chemical irriations. It has been also suggested that in diabetes mellitus the unmyelinated small diameter fibers are impaired as a result of diabetic neuropathy. Therefore, our aim was to study the alterations of the nerve processes in the gingivomucosal tissue in streptozotocin (STZ)-diabetic rats. Light- and electronmicroscopical examinations were made to analyze the changes in nerve fibres. After one week of steptozotocin treatment, the gingivomucosal tissue had inflammatory cell infiltration and some degenerated nerve fibres were also observed. Dense mitochondria, disorganization of cell organelles, and appearance of myelin-like dense bodies were found in the axons of degenerared nerve fibres. Semiquantitative analysis showed that 14 ± 4% of the unmyelinated nerve fibres degenerated after one week of STZ treatment. However, degeneration of the myelinated nerve fibers was not observed. Two weeks after STZ treatment, most of the unmyelinated and myelinated nerve fibers showed degeneration (86 ± 5%) and the placement of the ligature revealed a non-inflammatory connective tissue adjacent to a normal epithelium. The myelin sheath was disrupted and dark axoplasm with cytolysosomes became manifest. These findings demonstrated that both unmyelinated and myelinated nerve fibers are altered and inflammatory reaction exists in the gingivomucosal tissue only in the early stage of diabetes mellitus.

Original languageEnglish
Pages (from-to)230-233
Number of pages4
JournalArchives of Physiology and Biochemistry
Volume109
Issue number3 SPEC ISS.
DOIs
Publication statusPublished - Jul 2001

Fingerprint

Neurogenic Inflammation
Streptozocin
Nerve Fibers
Myelinated Nerve Fibers
Unmyelinated Nerve Fibers
Rats
Tissue
Fibers
Myelin Sheath
Diabetes Mellitus
Diabetic Neuropathies
Organelles
Connective Tissue
Medical problems
Ligation
Axons
Mitochondria
Epithelium
Light
Infiltration

Keywords

  • Diabetes mellitus
  • Electron microscopy
  • Gingiva
  • Inflammation
  • Morphometry
  • Nerve fibres
  • Oral tissue
  • Rat

ASJC Scopus subject areas

  • Physiology
  • Biochemistry

Cite this

Neurogenic inflammation of gingivomucosal tissue in streptozotocin-diabetic rat. / Fehér, E.; Gyorffi, A.; Fazekas, Á.

In: Archives of Physiology and Biochemistry, Vol. 109, No. 3 SPEC ISS., 07.2001, p. 230-233.

Research output: Contribution to journalArticle

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