Neuroendocrine and behavioral effects of vasopressin in resting and mild stress conditions

B. Buwalda, C. Nyakas, J. M. Koolhaas, B. Bohus

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Neuroendocrine and behavioral effects of subcutaneously administered AVP (6 μg/kg b.wt.) were determined in resting conditions and after the mild stress of transportation to and placement in a novel environment. In resting conditions, systemic administration of AVP caused a rapid increase in blood glucose level and a long-lasting increase in CORT secretion. A decrease in circulating plasma NE level was observed. AVP did not affect adrenal medullary E secretion. The stress-induced sympathetic activation, as reflected in plasma NE level, was inhibited 60 min after AVP administration. Stress-induced increases in blood glucose, CORT, and E secretion were not influenced by AVP. In resting condition, AVP caused a 60-min lasting increase in grooming behavior with a concomitant decrease in time spent resting. Sixty minutes after administration, the behavioral activation after the stress of transportation and placement in a novel environment was more rapidly terminated in AVP-treated rats than in vehicle-treated control rats. The state- and time-dependent modulation of spontaneous behavior suggests that AVP has arousing properties shortly after administration when marked pressor and endocrine effects are apparent. In a later phase, AVP may facilitate dearousal mechanisms following stress-induced behavioral activation.

Original languageEnglish
Pages (from-to)947-953
Number of pages7
JournalPhysiology and Behavior
Volume54
Issue number5
DOIs
Publication statusPublished - 1993

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Vasopressins
Blood Glucose
Grooming

Keywords

  • Blood glucose
  • Corticosterone
  • Physiology and behavior
  • Plasma catecholamines
  • Vasopressin

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Neuroendocrine and behavioral effects of vasopressin in resting and mild stress conditions. / Buwalda, B.; Nyakas, C.; Koolhaas, J. M.; Bohus, B.

In: Physiology and Behavior, Vol. 54, No. 5, 1993, p. 947-953.

Research output: Contribution to journalArticle

Buwalda, B. ; Nyakas, C. ; Koolhaas, J. M. ; Bohus, B. / Neuroendocrine and behavioral effects of vasopressin in resting and mild stress conditions. In: Physiology and Behavior. 1993 ; Vol. 54, No. 5. pp. 947-953.
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