Neurodegeneráció: öregedés és demencia. Elektrontranszport-zavar, mint etiopatogenetikai tényezó. Terápiás lehetóségek.

Translated title of the contribution: Neurodegeneration: aging and dementia. Etiopathogenic role of electron transport disorders. Therapeutic possibilities

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The neurodegenerative disorders (Parkinson's disease, Alzheimer's dementia, Huntington's disease, cerebellar degeneration) are common medical and social problems. The late onset diseases and slow neurodegeneration is connected with excitotoxins and alteration of mitochondrial electron transport chain. In elderly, congenital and acquired defects of mitochondrial complexes cause formation of free radicals. The overstimulation of excitatory amino acid receptors interfere with the cellular energy metabolism and also forming reactive oxygen species. The impaired energy metabolism make neuronal cells vulnerable to the excitotoxic damage. In these ways, excitotoxicity may be the final common pathway of neuronal death in a variety of neurodegenerative diseases. Potential therapeutic strategies would be use receptor antagonist or drugs to bypass energetic defects.

Translated title of the contributionNeurodegeneration: aging and dementia. Etiopathogenic role of electron transport disorders. Therapeutic possibilities
Original languageHungarian
Pages (from-to)331-335
Number of pages5
JournalOrvosi hetilap
Volume138
Issue number6
Publication statusPublished - Feb 9 1997

ASJC Scopus subject areas

  • Medicine(all)

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