Neurokognitív endofenotípusok a pszichiátriai genetikában

Translated title of the contribution: Neurocognitive endophenotypes in psychiatric genetics

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Psychiatric genetics aims to map genetic factors of psychiatric disorders with complex inheritance. The most commonly used phenotype is the categorical variable of the presence or absence of a disease (case-control model). However, the biological background of various psychiatric disease categories often overlaps. Thus, the use of endophenotypes based on specific biological mechanisms seems to be a more efficient approach in genetic association studies. Results confirm that categorical variables as phenotypes are statistically not so sensitive in identification of a genetic association as well-chosen endophenotypes. Current literature advocates a growing significance of analyzing dimensional neurocognitive endophenotypes in genetic association studies, as well as in developing diagnostic category systems with biological backgrounds.

Translated title of the contributionNeurocognitive endophenotypes in psychiatric genetics
Original languageHungarian
Pages (from-to)85-90
Number of pages6
JournalNeuropsychopharmacologia Hungarica
Volume16
Issue number2
Publication statusPublished - Jun 2014

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Clinical Neurology

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