Neurocirculatory regulation in cortisol-induced hypertension

K. Szemeredi, G. Bagdy, J. Kopin, D. S. Goldstein

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Effects of chronic glucocorticoid treatment on arterial baroreflex function and on cardiac β and vascular αadrenoceptor-mediated responses were assessed in conscious, unrestrained Wistar-Kyoto rats. Cortisol (25 mg/kg/day) was administered for seven days using a subcutaneous reservoir pump. Arterial baroreflex-cardiac sensitivity was assessed by examining the relationship of the cardiac interbeat interval to the mean arterial blood pressure during phenylephrine or nitroprusside challenge; baroreflex-sympathoneural sensitivity was assessed from the ratio of the increase in the arterial norepinephrine concentration to the decrease in mean arterial pressure at 15 min during intravenous infusion of nitroprusside; cardiac βadrenoceptor-mediated responsiveness was estimated from heart rate responses to bolus-injected isoproterenol; and vascular αadrenoceptor-mediated responsiveness was estimated from peak mean arterial pressure responses to bolus-injected phenylephrine. Cortisol treatment increased mean arterial pressure, decreased heart rate, and increased heart rate responses to isoproterenol, whereas baroreflex-vagal sensitivity, baroreflex-sympathoneural sensitivity, and pressor responses to phenylephrine were unaffected. The results indicate that hypertension due to chronic cortisol administration is not associated with decreased sensitivity of the baroreceptor-cardiac reflex. Baroreflex-sympathoneural sensitivity and α1-adrenoceptor responsiveness also remain normal, whereas βadrenoceptor responsiveness is increased. The findings suggest that the pattern of neurocirculatory adjustment in glucocorticoid hypertension differs from that seen in other forms of hypertension.

Original languageEnglish
Pages (from-to)1425-1439
Number of pages15
JournalClinical and Experimental Hypertension
VolumeA11
Issue number8
DOIs
Publication statusPublished - 1989
Externally publishedYes

Keywords

  • Adrenoceptors
  • Baroreflex
  • Cortisol
  • Dihydroxyphenylglycol
  • Epinephrine
  • Hypertension
  • Isoproterenol
  • Nitroprusside
  • Norepinephrine
  • Phenylephrine
  • Sympathetic Nervous System

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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