Neurochemical evidence for two types of presynaptic alpha2-adrenoceptors

Judit Kapocsi, George T. Somogyi, Nandor Ludvig, Peter Serfozo, Laszlo G. Harsing, Russell J. Woods, E. Sylvester Vizi

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28 Citations (Scopus)

Abstract

Neurochemical and pharmacological evidence has been obtained that noradrenergic varicosities (in mouse and rat vas deferens) and cholinergic varicosities (in the Auerbach's plexus) contain heterogenous alpha2-adrenoceptors through which the release of [3H]noradrenaline and [3H]acetylcholine can be modulated. The quantitative data also support the hypothesis that different noradrenaline and xylazine sensitive alpha2-adrenoceptors are present prejunctionally in the vas deferens and Auerbach's plexus preparations. Prazosin, although it has a presynaptic inhibitory effect on alpha2-adrenoceptors of noradrenergic axon terminals, has no effect on cholinergic axon terminals. These data suggest that there are two different types of alpha2-adrenoceptors at the presynaptic axon terminals.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalNeurochemical research
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 1 1987

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Keywords

  • Prazosin
  • [H]Noradrenaline release
  • dissociation of alpha-adrenoceptors
  • presynaptic alpha-adrenoceptors

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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