Neurochemical evidence for two types of presynaptic alpha2-adrenoceptors

Judit Kapocsi, George T. Somogyi, Nandor Ludvig, Peter Serfozo, L. Hársing, Russell J. Woods, E. Vízi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Neurochemical and pharmacological evidence has been obtained that noradrenergic varicosities (in mouse and rat vas deferens) and cholinergic varicosities (in the Auerbach's plexus) contain heterogenous alpha2-adrenoceptors through which the release of [3H]noradrenaline and [3H]acetylcholine can be modulated. The quantitative data also support the hypothesis that different noradrenaline and xylazine sensitive alpha2-adrenoceptors are present prejunctionally in the vas deferens and Auerbach's plexus preparations. Prazosin, although it has a presynaptic inhibitory effect on alpha2-adrenoceptors of noradrenergic axon terminals, has no effect on cholinergic axon terminals. These data suggest that there are two different types of alpha2-adrenoceptors at the presynaptic axon terminals.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalNeurochemical Research
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 1987

Fingerprint

Presynaptic Terminals
Adrenergic Receptors
Myenteric Plexus
Vas Deferens
Cholinergic Agents
Norepinephrine
Xylazine
Prazosin
Acetylcholine
Rats
Pharmacology
Axons

Keywords

  • [H]Noradrenaline release
  • dissociation of alpha-adrenoceptors
  • Prazosin
  • presynaptic alpha-adrenoceptors

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Neurochemical evidence for two types of presynaptic alpha2-adrenoceptors. / Kapocsi, Judit; Somogyi, George T.; Ludvig, Nandor; Serfozo, Peter; Hársing, L.; Woods, Russell J.; Vízi, E.

In: Neurochemical Research, Vol. 12, No. 2, 02.1987, p. 141-147.

Research output: Contribution to journalArticle

Kapocsi, Judit ; Somogyi, George T. ; Ludvig, Nandor ; Serfozo, Peter ; Hársing, L. ; Woods, Russell J. ; Vízi, E. / Neurochemical evidence for two types of presynaptic alpha2-adrenoceptors. In: Neurochemical Research. 1987 ; Vol. 12, No. 2. pp. 141-147.
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