Neurochemical evidence for the release of acetylcholine from the guinea-pig ileum myenteric plexus by capsaicin

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Superfision of the sensory stimulant drug capsaicin (3.3 μM) released [3H]acetylcholine from isolated myenteric plexus-longitudinal muscle strips of guinea-pig ileum, preincubated with [3H]choline. This effect was prevented by tetrodotoxin. There was a fast tachyphylaxis to the effect of capsaicin. It is suggested that capsaicin-sensitive nerve endings capable of activating intrinsic cholinergic neurones are situated in the myenteric plexus of the guinea-pig ileum.

Original languageEnglish
Pages (from-to)125-127
Number of pages3
JournalEuropean Journal of Pharmacology
Issue number1
Publication statusPublished - Mar 26 1985



  • Capsaicin
  • Myenteric plexus
  • [H]Acetylcholine release

ASJC Scopus subject areas

  • Pharmacology

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