A premenstruális szindróma és a szerotonerg funkciók összefüggései.

Translated title of the contribution: Neurochemical background of the premenstrual syndrome: the role of the serotonergic system

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Current research focusing on the biological background of premenstrual syndrome suggests that both psychological and physiological factors exert their effect by means of the dysregulation of the serotonergic function. The results of several studies point to a variation in the function of the serotonergic system throughout the cycle, which is related to the plasma concentration of the gonadal steroid hormones. Certain parameters of serotonergic function show different values in the different phases of the cycle. The rise in oestrogen concentration is followed by an increase in the 5HT2A receptor expression in brain areas responsible for mood, emotion, cognition and neuroendocrine regulation. The role of serotonin is further supported by its role in depression, anxiety, aggression as well as the efficiency of serotonergic agents in the treatment of premenstrual syndrome. In our article we review the main theories concerning the biological background of the premenstrual syndrome, and we outline in detail the role of the serotonergic system. We review the research on the relationship between serotonergic function and gonadal steroid levels as well as the latest results concerning the state- and trait-like parameters of the serotonergic system. The studies reviewed provide evidence for the relationship between the gonadal steroid function and the serotonergic system. Further research is necessary in order to determine why the cycle-dependent variation in the function of the serotonergic system leads to the development of premenstrual syndrome only in vulnerable women.

Original languageHungarian
Pages (from-to)153-162
Number of pages10
JournalNeuropsychopharmacologia Hungarica
Volume6
Issue number3
Publication statusPublished - 2004

Fingerprint

Premenstrual Syndrome
Steroids
Research
Serotonin Agents
Gonadal Steroid Hormones
Aggression
Cognition
Serotonin
Emotions
Estrogens
Anxiety
Depression
Psychology
Brain

Cite this

A premenstruális szindróma és a szerotonerg funkciók összefüggései. / Gonda, X.; Bagdy, G.

In: Neuropsychopharmacologia Hungarica, Vol. 6, No. 3, 2004, p. 153-162.

Research output: Contribution to journalArticle

@article{9fe143e8cc184e5098f14342046dfca8,
title = "A premenstru{\'a}lis szindr{\'o}ma {\'e}s a szerotonerg funkci{\'o}k {\"o}sszef{\"u}gg{\'e}sei.",
abstract = "Current research focusing on the biological background of premenstrual syndrome suggests that both psychological and physiological factors exert their effect by means of the dysregulation of the serotonergic function. The results of several studies point to a variation in the function of the serotonergic system throughout the cycle, which is related to the plasma concentration of the gonadal steroid hormones. Certain parameters of serotonergic function show different values in the different phases of the cycle. The rise in oestrogen concentration is followed by an increase in the 5HT2A receptor expression in brain areas responsible for mood, emotion, cognition and neuroendocrine regulation. The role of serotonin is further supported by its role in depression, anxiety, aggression as well as the efficiency of serotonergic agents in the treatment of premenstrual syndrome. In our article we review the main theories concerning the biological background of the premenstrual syndrome, and we outline in detail the role of the serotonergic system. We review the research on the relationship between serotonergic function and gonadal steroid levels as well as the latest results concerning the state- and trait-like parameters of the serotonergic system. The studies reviewed provide evidence for the relationship between the gonadal steroid function and the serotonergic system. Further research is necessary in order to determine why the cycle-dependent variation in the function of the serotonergic system leads to the development of premenstrual syndrome only in vulnerable women.",
author = "X. Gonda and G. Bagdy",
year = "2004",
language = "Hungarian",
volume = "6",
pages = "153--162",
journal = "Neuropsychopharmacologia Hungarica",
issn = "1419-8711",
publisher = "Hungarian Association of Psychopharmacology",
number = "3",

}

TY - JOUR

T1 - A premenstruális szindróma és a szerotonerg funkciók összefüggései.

AU - Gonda, X.

AU - Bagdy, G.

PY - 2004

Y1 - 2004

N2 - Current research focusing on the biological background of premenstrual syndrome suggests that both psychological and physiological factors exert their effect by means of the dysregulation of the serotonergic function. The results of several studies point to a variation in the function of the serotonergic system throughout the cycle, which is related to the plasma concentration of the gonadal steroid hormones. Certain parameters of serotonergic function show different values in the different phases of the cycle. The rise in oestrogen concentration is followed by an increase in the 5HT2A receptor expression in brain areas responsible for mood, emotion, cognition and neuroendocrine regulation. The role of serotonin is further supported by its role in depression, anxiety, aggression as well as the efficiency of serotonergic agents in the treatment of premenstrual syndrome. In our article we review the main theories concerning the biological background of the premenstrual syndrome, and we outline in detail the role of the serotonergic system. We review the research on the relationship between serotonergic function and gonadal steroid levels as well as the latest results concerning the state- and trait-like parameters of the serotonergic system. The studies reviewed provide evidence for the relationship between the gonadal steroid function and the serotonergic system. Further research is necessary in order to determine why the cycle-dependent variation in the function of the serotonergic system leads to the development of premenstrual syndrome only in vulnerable women.

AB - Current research focusing on the biological background of premenstrual syndrome suggests that both psychological and physiological factors exert their effect by means of the dysregulation of the serotonergic function. The results of several studies point to a variation in the function of the serotonergic system throughout the cycle, which is related to the plasma concentration of the gonadal steroid hormones. Certain parameters of serotonergic function show different values in the different phases of the cycle. The rise in oestrogen concentration is followed by an increase in the 5HT2A receptor expression in brain areas responsible for mood, emotion, cognition and neuroendocrine regulation. The role of serotonin is further supported by its role in depression, anxiety, aggression as well as the efficiency of serotonergic agents in the treatment of premenstrual syndrome. In our article we review the main theories concerning the biological background of the premenstrual syndrome, and we outline in detail the role of the serotonergic system. We review the research on the relationship between serotonergic function and gonadal steroid levels as well as the latest results concerning the state- and trait-like parameters of the serotonergic system. The studies reviewed provide evidence for the relationship between the gonadal steroid function and the serotonergic system. Further research is necessary in order to determine why the cycle-dependent variation in the function of the serotonergic system leads to the development of premenstrual syndrome only in vulnerable women.

UR - http://www.scopus.com/inward/record.url?scp=18744412368&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18744412368&partnerID=8YFLogxK

M3 - Article

C2 - 15816306

AN - SCOPUS:18744412368

VL - 6

SP - 153

EP - 162

JO - Neuropsychopharmacologia Hungarica

JF - Neuropsychopharmacologia Hungarica

SN - 1419-8711

IS - 3

ER -