A kognitív rugalmasság neurobiológiai korrelátumainak vizsgálata ADHD-ban lrodalmi áttekintés

Translated title of the contribution: Neurobiological correlates of cognitive flexibility in ADHD - A systematic review of the literature

Sára Bálint, I. Bitter, P. Czobor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

INTRODUCTION: Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed childhood psychiatric disorders, which persists to adulthood in 30-50% of the cases. Previous studies have shown that cognitive flexibility, which means to switch between two different rules, that can be tested with task switching paradigms, is affected. Although poor performance in cognitive flexibility tests has been demostrated, the neurobiological background is only partly known.

OBJECTIVE: The aim of our review was to examine the neurobiological background of impairment of cognitive flexibility in ADHD, with a specific focus on functional MRI (fMRI) and electrophysiological (electroencephalography, EEG) studies.

METHODS: We searched MEDLINE, PubMed, and PsychInfo using the following keywords: 'ADHD', 'cognitive flexibility', 'set shifting', 'task switching', 'EEG', 'fMRI'.

RESULTS: Compared to healthy controls, ADHD patients showed reduced activation in regions of the prefrontal and parietal lobe and in the basal ganglia. However in two studies, increased activation was also observed in specific regions of temporal lobe and in anterior cingulate cortex. Magnetoencephalographic results indicated that instead of an increased activity in medio-temporal lobe, ADHD patients showed an enhanced activation in the superior temporal gyrus and in the left inferior parietal lobe.

CONCLUSIONS: Based on our review, patients with ADHD, as compared to healthy controls, showed reduced activation in brain regions associated with cognitive flexibility. Based on the differences in the spatial and temporal patterns of activation in the temporal lobe we conclude that ADHD patient engage different brain regions to resolve the conflicts caused by task switching. However, further studies are required to corroborate this conclusion.

Original languageHungarian
Pages (from-to)363-371
Number of pages9
JournalPsychiatria Hungarica : A Magyar Pszichiátriai Társaság tudományos folyóirata
Volume30
Issue number4
Publication statusPublished - 2015

Fingerprint

Attention Deficit Disorder with Hyperactivity
Temporal Lobe
Parietal Lobe
Electroencephalography
Magnetic Resonance Imaging
Gyrus Cinguli
Brain
Basal Ganglia
PubMed
MEDLINE
Psychiatry

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "A kognit{\'i}v rugalmass{\'a}g neurobiol{\'o}giai korrel{\'a}tumainak vizsg{\'a}lata ADHD-ban lrodalmi {\'a}ttekint{\'e}s",
abstract = "INTRODUCTION: Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed childhood psychiatric disorders, which persists to adulthood in 30-50{\%} of the cases. Previous studies have shown that cognitive flexibility, which means to switch between two different rules, that can be tested with task switching paradigms, is affected. Although poor performance in cognitive flexibility tests has been demostrated, the neurobiological background is only partly known.OBJECTIVE: The aim of our review was to examine the neurobiological background of impairment of cognitive flexibility in ADHD, with a specific focus on functional MRI (fMRI) and electrophysiological (electroencephalography, EEG) studies.METHODS: We searched MEDLINE, PubMed, and PsychInfo using the following keywords: 'ADHD', 'cognitive flexibility', 'set shifting', 'task switching', 'EEG', 'fMRI'.RESULTS: Compared to healthy controls, ADHD patients showed reduced activation in regions of the prefrontal and parietal lobe and in the basal ganglia. However in two studies, increased activation was also observed in specific regions of temporal lobe and in anterior cingulate cortex. Magnetoencephalographic results indicated that instead of an increased activity in medio-temporal lobe, ADHD patients showed an enhanced activation in the superior temporal gyrus and in the left inferior parietal lobe.CONCLUSIONS: Based on our review, patients with ADHD, as compared to healthy controls, showed reduced activation in brain regions associated with cognitive flexibility. Based on the differences in the spatial and temporal patterns of activation in the temporal lobe we conclude that ADHD patient engage different brain regions to resolve the conflicts caused by task switching. However, further studies are required to corroborate this conclusion.",
author = "S{\'a}ra B{\'a}lint and I. Bitter and P. Czobor",
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AU - Czobor, P.

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N2 - INTRODUCTION: Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed childhood psychiatric disorders, which persists to adulthood in 30-50% of the cases. Previous studies have shown that cognitive flexibility, which means to switch between two different rules, that can be tested with task switching paradigms, is affected. Although poor performance in cognitive flexibility tests has been demostrated, the neurobiological background is only partly known.OBJECTIVE: The aim of our review was to examine the neurobiological background of impairment of cognitive flexibility in ADHD, with a specific focus on functional MRI (fMRI) and electrophysiological (electroencephalography, EEG) studies.METHODS: We searched MEDLINE, PubMed, and PsychInfo using the following keywords: 'ADHD', 'cognitive flexibility', 'set shifting', 'task switching', 'EEG', 'fMRI'.RESULTS: Compared to healthy controls, ADHD patients showed reduced activation in regions of the prefrontal and parietal lobe and in the basal ganglia. However in two studies, increased activation was also observed in specific regions of temporal lobe and in anterior cingulate cortex. Magnetoencephalographic results indicated that instead of an increased activity in medio-temporal lobe, ADHD patients showed an enhanced activation in the superior temporal gyrus and in the left inferior parietal lobe.CONCLUSIONS: Based on our review, patients with ADHD, as compared to healthy controls, showed reduced activation in brain regions associated with cognitive flexibility. Based on the differences in the spatial and temporal patterns of activation in the temporal lobe we conclude that ADHD patient engage different brain regions to resolve the conflicts caused by task switching. However, further studies are required to corroborate this conclusion.

AB - INTRODUCTION: Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed childhood psychiatric disorders, which persists to adulthood in 30-50% of the cases. Previous studies have shown that cognitive flexibility, which means to switch between two different rules, that can be tested with task switching paradigms, is affected. Although poor performance in cognitive flexibility tests has been demostrated, the neurobiological background is only partly known.OBJECTIVE: The aim of our review was to examine the neurobiological background of impairment of cognitive flexibility in ADHD, with a specific focus on functional MRI (fMRI) and electrophysiological (electroencephalography, EEG) studies.METHODS: We searched MEDLINE, PubMed, and PsychInfo using the following keywords: 'ADHD', 'cognitive flexibility', 'set shifting', 'task switching', 'EEG', 'fMRI'.RESULTS: Compared to healthy controls, ADHD patients showed reduced activation in regions of the prefrontal and parietal lobe and in the basal ganglia. However in two studies, increased activation was also observed in specific regions of temporal lobe and in anterior cingulate cortex. Magnetoencephalographic results indicated that instead of an increased activity in medio-temporal lobe, ADHD patients showed an enhanced activation in the superior temporal gyrus and in the left inferior parietal lobe.CONCLUSIONS: Based on our review, patients with ADHD, as compared to healthy controls, showed reduced activation in brain regions associated with cognitive flexibility. Based on the differences in the spatial and temporal patterns of activation in the temporal lobe we conclude that ADHD patient engage different brain regions to resolve the conflicts caused by task switching. However, further studies are required to corroborate this conclusion.

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