Neurobiochemical changes in the vicinity of a nanostructured neural implant

Zsófia Bérces, Kinga Tóth, Gergely Márton, Ildikó Pál, Bálint Kováts-Megyesi, Zoltán Fekete, I. Ulbert, Anita Pongrácz

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Neural interface technologies including recording and stimulation electrodes are currently in the early phase of clinical trials aiming to help patients with spinal cord injuries, degenerative disorders, strokes interrupting descending motor pathways, or limb amputations. Their lifetime is of key importance; however, it is limited by the foreign body response of the tissue causing the loss of neurons and a reactive astrogliosis around the implant surface. Improving the biocompatibility of implant surfaces, especially promoting neuronal attachment and regeneration is therefore essential. In our work, bioactive properties of implanted black polySi nanostructured surfaces (520-800 nm long nanopillars with a diameter of 150-200 nm) were investigated and compared to microstructured Si surfaces in eight-week-long in vivo experiments. Glial encapsulation and local neuronal cell loss were characterised using GFAP and NeuN immunostaining respectively, followed by systematic image analysis. Regarding the severity of gliosis, no significant difference was observed in the vicinity of the different implant surfaces, however, the number of surviving neurons close to the nanostructured surface was higher than that of the microstructured ones. Our results imply that the functionality of implanted microelectrodes covered by Si nanopillars may lead to improved long-term recordings.

Original languageEnglish
Article number35944
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - Oct 24 2016

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Efferent Pathways
Neurons
Gliosis
Microelectrodes
Foreign Bodies
Spinal Cord Injuries
Amputation
Neuroglia
Regeneration
Electrodes
Extremities
Stroke
Clinical Trials
Technology

ASJC Scopus subject areas

  • General

Cite this

Bérces, Z., Tóth, K., Márton, G., Pál, I., Kováts-Megyesi, B., Fekete, Z., ... Pongrácz, A. (2016). Neurobiochemical changes in the vicinity of a nanostructured neural implant. Scientific Reports, 6, [35944]. https://doi.org/10.1038/srep35944

Neurobiochemical changes in the vicinity of a nanostructured neural implant. / Bérces, Zsófia; Tóth, Kinga; Márton, Gergely; Pál, Ildikó; Kováts-Megyesi, Bálint; Fekete, Zoltán; Ulbert, I.; Pongrácz, Anita.

In: Scientific Reports, Vol. 6, 35944, 24.10.2016.

Research output: Contribution to journalArticle

Bérces, Z, Tóth, K, Márton, G, Pál, I, Kováts-Megyesi, B, Fekete, Z, Ulbert, I & Pongrácz, A 2016, 'Neurobiochemical changes in the vicinity of a nanostructured neural implant', Scientific Reports, vol. 6, 35944. https://doi.org/10.1038/srep35944
Bérces Z, Tóth K, Márton G, Pál I, Kováts-Megyesi B, Fekete Z et al. Neurobiochemical changes in the vicinity of a nanostructured neural implant. Scientific Reports. 2016 Oct 24;6. 35944. https://doi.org/10.1038/srep35944
Bérces, Zsófia ; Tóth, Kinga ; Márton, Gergely ; Pál, Ildikó ; Kováts-Megyesi, Bálint ; Fekete, Zoltán ; Ulbert, I. ; Pongrácz, Anita. / Neurobiochemical changes in the vicinity of a nanostructured neural implant. In: Scientific Reports. 2016 ; Vol. 6.
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