Neural inputs of the hypothalamic "aggression area" in the rat

Mate Toth, Tamas Fuzesi, Jozsef Halasz, Aron Tulogdi, Jozsef Haller

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A part of the mediobasal hypothalamus (known as hypothalamic attack area) plays a central role in the control of aggressive behavior as its electrical stimulation reliably and rapidly elicits biting attacks in cats and rodents. The efferent connections of this brain region were described in rats, but afferent pathways were not investigated so far. We injected the retrograde tracer cholera toxin B subunit into the mediobasal hypothalamus of male Wistar rats and studied the distribution of labeled cells by immunohistochemical method. The retrograde labeling outlined three continuous, distinct afferent cell populations: (i) a telencephalic midline " plate" containing the orbitofrontal - medial prefrontal - septal regions which ends in the bed nucleus of stria terminalis; (ii) a temporal column including the medial amygdala, amigdalohippocampal area and subiculum; (iii) a diffuse column along the medial hypothalamus which ends in the posterior hypothalamic nucleus. Sparse labeling was present in brainstem nuclei, except for the lateral parabrachial nucleus that provides a significant input. The projections of the medial prefrontal cortex to the hypothalamic attack area indicate a direct, earlier undescribed pathway with marked importance in the control of aggressive behavior. Similarly, we identified several brain regions which send very significant projections to the hypothalamic attack area but their importance in the control of aggressive behavior are nearly unknown. The comparison of the present and earlier findings shows that efferent and afferent connections overlap in many regions to a significant extent, suggesting that reverberating circuits are important in the control of aggressive behavior.

Original languageEnglish
Pages (from-to)7-20
Number of pages14
JournalBehavioural Brain Research
Volume215
Issue number1
DOIs
Publication statusPublished - Dec 1 2010

    Fingerprint

Keywords

  • Afferent connections
  • Aggression
  • Hypothalamic attack area
  • Hypothalamus
  • Retrograde tracer

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this