Neural control of ovulation

B. Halász, K. Köves, J. Molnár

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Pituitary gonadotrophin function is controlled to a great extent by the central nervous system and by the feedback action (positive and negative) of sex steroids. Neural structures involved in this mechanism may be divided into two levels. The first level is represented by the nervous structures releasing gonadotrophin-releasing hormone (GnRH) in a pulsatile manner into the portal circulation. The gene encoding the precursor protein for GnRH has been descnbed recently. The precursor protein appears to be composed of 92 amino acids, in which the GnRH decapeptide is preceded by a signal pep-tide and followed by a peptide termed GAP for GnRH-associated peptide. The GnRH-syntheslzing neurones and the nervous structures synchronizing the GnRH discharge (pulse generator) in the monkey, and probably also in the human, reside in the medial basal hypothalamus, which appears to have a highly integrated structure. The GnRH pulse generator is influenced by nervous structures outside the medial basal hypothalamus (second level of control) as well as by ovarian and other hormones. These influences probably impinge directly or indirectly on the hypothalamic oscillator. Concerning the chemical nature of the substances mediating the action, a large number of neurotransmitters and neuropeptides have been reported to influence GnRH secretion.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalHuman Reproduction
Volume3
Issue number1
Publication statusPublished - Jan 1988

Fingerprint

Ovulation
Neural Control
Gonadotropins
Hormones
Gonadotropin-Releasing Hormone
Middle Hypothalamus
Protein Precursors
Pulse generators
Peptides
Precursor
Pituitary Gonadotropins
Proteins
Generator
Gene encoding
Protein
Neuropeptides
Tides
Steroids
Neurology
Tide

Keywords

  • Central nervous system
  • GnRH
  • Gonadotrophins
  • Sex steroids

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Rehabilitation
  • Developmental Biology
  • Physiology

Cite this

Neural control of ovulation. / Halász, B.; Köves, K.; Molnár, J.

In: Human Reproduction, Vol. 3, No. 1, 01.1988, p. 33-37.

Research output: Contribution to journalArticle

Halász, B, Köves, K & Molnár, J 1988, 'Neural control of ovulation', Human Reproduction, vol. 3, no. 1, pp. 33-37.
Halász, B. ; Köves, K. ; Molnár, J. / Neural control of ovulation. In: Human Reproduction. 1988 ; Vol. 3, No. 1. pp. 33-37.
@article{2c55fd10f3c54844914db260f7e56848,
title = "Neural control of ovulation",
abstract = "Pituitary gonadotrophin function is controlled to a great extent by the central nervous system and by the feedback action (positive and negative) of sex steroids. Neural structures involved in this mechanism may be divided into two levels. The first level is represented by the nervous structures releasing gonadotrophin-releasing hormone (GnRH) in a pulsatile manner into the portal circulation. The gene encoding the precursor protein for GnRH has been descnbed recently. The precursor protein appears to be composed of 92 amino acids, in which the GnRH decapeptide is preceded by a signal pep-tide and followed by a peptide termed GAP for GnRH-associated peptide. The GnRH-syntheslzing neurones and the nervous structures synchronizing the GnRH discharge (pulse generator) in the monkey, and probably also in the human, reside in the medial basal hypothalamus, which appears to have a highly integrated structure. The GnRH pulse generator is influenced by nervous structures outside the medial basal hypothalamus (second level of control) as well as by ovarian and other hormones. These influences probably impinge directly or indirectly on the hypothalamic oscillator. Concerning the chemical nature of the substances mediating the action, a large number of neurotransmitters and neuropeptides have been reported to influence GnRH secretion.",
keywords = "Central nervous system, GnRH, Gonadotrophins, Sex steroids",
author = "B. Hal{\'a}sz and K. K{\"o}ves and J. Moln{\'a}r",
year = "1988",
month = "1",
language = "English",
volume = "3",
pages = "33--37",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Neural control of ovulation

AU - Halász, B.

AU - Köves, K.

AU - Molnár, J.

PY - 1988/1

Y1 - 1988/1

N2 - Pituitary gonadotrophin function is controlled to a great extent by the central nervous system and by the feedback action (positive and negative) of sex steroids. Neural structures involved in this mechanism may be divided into two levels. The first level is represented by the nervous structures releasing gonadotrophin-releasing hormone (GnRH) in a pulsatile manner into the portal circulation. The gene encoding the precursor protein for GnRH has been descnbed recently. The precursor protein appears to be composed of 92 amino acids, in which the GnRH decapeptide is preceded by a signal pep-tide and followed by a peptide termed GAP for GnRH-associated peptide. The GnRH-syntheslzing neurones and the nervous structures synchronizing the GnRH discharge (pulse generator) in the monkey, and probably also in the human, reside in the medial basal hypothalamus, which appears to have a highly integrated structure. The GnRH pulse generator is influenced by nervous structures outside the medial basal hypothalamus (second level of control) as well as by ovarian and other hormones. These influences probably impinge directly or indirectly on the hypothalamic oscillator. Concerning the chemical nature of the substances mediating the action, a large number of neurotransmitters and neuropeptides have been reported to influence GnRH secretion.

AB - Pituitary gonadotrophin function is controlled to a great extent by the central nervous system and by the feedback action (positive and negative) of sex steroids. Neural structures involved in this mechanism may be divided into two levels. The first level is represented by the nervous structures releasing gonadotrophin-releasing hormone (GnRH) in a pulsatile manner into the portal circulation. The gene encoding the precursor protein for GnRH has been descnbed recently. The precursor protein appears to be composed of 92 amino acids, in which the GnRH decapeptide is preceded by a signal pep-tide and followed by a peptide termed GAP for GnRH-associated peptide. The GnRH-syntheslzing neurones and the nervous structures synchronizing the GnRH discharge (pulse generator) in the monkey, and probably also in the human, reside in the medial basal hypothalamus, which appears to have a highly integrated structure. The GnRH pulse generator is influenced by nervous structures outside the medial basal hypothalamus (second level of control) as well as by ovarian and other hormones. These influences probably impinge directly or indirectly on the hypothalamic oscillator. Concerning the chemical nature of the substances mediating the action, a large number of neurotransmitters and neuropeptides have been reported to influence GnRH secretion.

KW - Central nervous system

KW - GnRH

KW - Gonadotrophins

KW - Sex steroids

UR - http://www.scopus.com/inward/record.url?scp=0023845254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023845254&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 33

EP - 37

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 1

ER -