Network analysis of protein dynamics

Csaba Böde, István A. Kovács, M. Szalay, Robin Palotai, T. Korcsmáros, P. Csermely

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

The network paradigm is increasingly used to describe the topology and dynamics of complex systems. Here, we review the results of the topological analysis of protein structures as molecular networks describing their small-world character, and the role of hubs and central network elements in governing enzyme activity, allosteric regulation, protein motor function, signal transduction and protein stability. We summarize available data how central network elements are enriched in active centers and ligand binding sites directing the dynamics of the entire protein. We assess the feasibility of conformational and energy networks to simplify the vast complexity of rugged energy landscapes and to predict protein folding and dynamics. Finally, we suggest that modular analysis, novel centrality measures, hierarchical representation of networks and the analysis of network dynamics will soon lead to an expansion of this field.

Original languageEnglish
Pages (from-to)2776-2782
Number of pages7
JournalFEBS Letters
Volume581
Issue number15
DOIs
Publication statusPublished - Jun 19 2007

Fingerprint

Electric network analysis
Allosteric Regulation
Proteins
Protein Stability
Protein Folding
Molecular Structure
Protein folding
Signal transduction
Signal Transduction
Enzyme activity
Binding Sites
Ligands
Large scale systems
Topology
Enzymes

Keywords

  • Allosteric regulation
  • Disordered proteins
  • Enzyme catalysis
  • Molecular machines
  • Motions
  • Network topology
  • Protein structure
  • Signal transduction
  • Small-world
  • Water

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Network analysis of protein dynamics. / Böde, Csaba; Kovács, István A.; Szalay, M.; Palotai, Robin; Korcsmáros, T.; Csermely, P.

In: FEBS Letters, Vol. 581, No. 15, 19.06.2007, p. 2776-2782.

Research output: Contribution to journalArticle

Böde, Csaba ; Kovács, István A. ; Szalay, M. ; Palotai, Robin ; Korcsmáros, T. ; Csermely, P. / Network analysis of protein dynamics. In: FEBS Letters. 2007 ; Vol. 581, No. 15. pp. 2776-2782.
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