Nervous system effects of dissolved and nanoparticulate cadmium in rats in subacute exposure

Edina Horváth, Gábor Oszlánczi, Zsuzsanna Máté, A. Szabó, Gábor Kozma, András Sápi, Z. Kónya, Edit Paulik, L. Nagymajtényi, A. Papp

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cadmium, a toxic heavy metal with various applications in technology, can affect people both by environmental (foodborne) and occupational (inhalation) exposure and can cause nervous system damage. To model this, rats were subacutely treated either with CdCl 2 solution per os (3.0mg kg -1 b.w.) or nanoparticulate CdO 2 (particle size ca 65nm) by intratracheal instillation (0.04mg kg -1 b.w.) alone or in sequential combination. Nervous system effects were observed at different levels of function (open field behavior, cortical electrical activity, nerve action potential) and some general toxicological indicators were also measured. Three weeks of oral plus one week of intratracheal exposure caused significant reduction of body weight gain and open field motility. Lengthening of latency of sensory evoked potentials, observed in all treated rats, was also the most significant in the group receiving oral plus intratracheal treatment. Conduction velocity of the tail nerve was likewise decreased in all treated groups. Several of the effects pointed to a potentiating interaction between the two forms of Cd. Modeling environmental and occupational Cd exposure by oral and intratracheal application in rats was feasible, with results suggesting serious negative health effects in humans suffering such a combined exposure.

Original languageEnglish
Pages (from-to)471-476
Number of pages6
JournalJournal of Applied Toxicology
Volume31
Issue number5
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Neurology
Cadmium
Nervous System
Rats
Occupational Exposure
Inhalation Exposure
Poisons
Bioelectric potentials
Heavy Metals
Evoked Potentials
Particle Size
Toxicology
Action Potentials
Weight Gain
Tail
Particle size
Body Weight
Health
Technology

Keywords

  • Behavioral toxicity
  • Cadmium
  • Nanoparticle
  • Neurotoxicity
  • Rat

ASJC Scopus subject areas

  • Toxicology

Cite this

Nervous system effects of dissolved and nanoparticulate cadmium in rats in subacute exposure. / Horváth, Edina; Oszlánczi, Gábor; Máté, Zsuzsanna; Szabó, A.; Kozma, Gábor; Sápi, András; Kónya, Z.; Paulik, Edit; Nagymajtényi, L.; Papp, A.

In: Journal of Applied Toxicology, Vol. 31, No. 5, 07.2011, p. 471-476.

Research output: Contribution to journalArticle

Horváth, Edina ; Oszlánczi, Gábor ; Máté, Zsuzsanna ; Szabó, A. ; Kozma, Gábor ; Sápi, András ; Kónya, Z. ; Paulik, Edit ; Nagymajtényi, L. ; Papp, A. / Nervous system effects of dissolved and nanoparticulate cadmium in rats in subacute exposure. In: Journal of Applied Toxicology. 2011 ; Vol. 31, No. 5. pp. 471-476.
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