Nerve-sparing radical hysterectomy for Stage IA2-IIB cervical cancer

5-Year survival of 501 consecutive cases

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15 Citations (Scopus)

Abstract

Objective: The purpose of this study was to assess the 5-year survival and morbidity in cases with radical hysterectomy and pelvic lymphadenectomy with pre- and postoperative irradiation performed to treat Stage IA2-IIB cervical cancer. Methods: During a 101/2-year period between July 1990 and December 2000, 501 consecutive radical hysterectomies with bilateral pelvic lymphadenectomy were performed by the same gynecological surgeon in Stage IA2, IB, IIA and IIB cervical cancer. The patients were treated by pre- and postoperative irradiation as well. Results: Apart from recurrence, perioperative complications were minimal with no long-term morbidity. The absolute 5-year survival rates for the patients in Stage IA2, IB1, IB2, IIA and IIB were 94.4%, 90.7%, 84.1%, 71.1%, and 55.4%, respectively. The respective 5-year survival rates for patients without or with lymph node metastasis were 94.5% and 33.3% in Stage IB2, 81.7% and 48.7% in Stage IIA and 70.2% and 36.5% in Stage IIB, respectively. Conclusions: Nerve-sparing radical hysterectomy with pelvic lymph node dissection and pre- and postoperative irradiation remains the treatment of choice for most patients with early-stage and even Stage IIB cervical cancer. The radicalism and extent of lymph node dissection and parametrial resection should be individualized and tailored to tumor- and patient-related risk factors.

Original languageEnglish
Pages (from-to)553-560
Number of pages8
JournalEuropean Journal of Gynaecological Oncology
Volume27
Issue number6
Publication statusPublished - 2006

Fingerprint

Hysterectomy
Uterine Cervical Neoplasms
Lymph Node Excision
Survival
Survival Rate
Morbidity
Lymph Nodes
Neoplasm Metastasis
Recurrence
Neoplasms
Therapeutics

Keywords

  • 5-Year survival
  • Cervical cancer
  • Nerve-sparing radical hysterectomy
  • Pelvic lymphadenectomy
  • Pre- and postoperative irradiation
  • Wertheim operation

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

@article{560ef29b1c0c42a78ebf85a895b70960,
title = "Nerve-sparing radical hysterectomy for Stage IA2-IIB cervical cancer: 5-Year survival of 501 consecutive cases",
abstract = "Objective: The purpose of this study was to assess the 5-year survival and morbidity in cases with radical hysterectomy and pelvic lymphadenectomy with pre- and postoperative irradiation performed to treat Stage IA2-IIB cervical cancer. Methods: During a 101/2-year period between July 1990 and December 2000, 501 consecutive radical hysterectomies with bilateral pelvic lymphadenectomy were performed by the same gynecological surgeon in Stage IA2, IB, IIA and IIB cervical cancer. The patients were treated by pre- and postoperative irradiation as well. Results: Apart from recurrence, perioperative complications were minimal with no long-term morbidity. The absolute 5-year survival rates for the patients in Stage IA2, IB1, IB2, IIA and IIB were 94.4{\%}, 90.7{\%}, 84.1{\%}, 71.1{\%}, and 55.4{\%}, respectively. The respective 5-year survival rates for patients without or with lymph node metastasis were 94.5{\%} and 33.3{\%} in Stage IB2, 81.7{\%} and 48.7{\%} in Stage IIA and 70.2{\%} and 36.5{\%} in Stage IIB, respectively. Conclusions: Nerve-sparing radical hysterectomy with pelvic lymph node dissection and pre- and postoperative irradiation remains the treatment of choice for most patients with early-stage and even Stage IIB cervical cancer. The radicalism and extent of lymph node dissection and parametrial resection should be individualized and tailored to tumor- and patient-related risk factors.",
keywords = "5-Year survival, Cervical cancer, Nerve-sparing radical hysterectomy, Pelvic lymphadenectomy, Pre- and postoperative irradiation, Wertheim operation",
author = "Z. Papp and Z. Csap{\'o} and P. Hupuczi and {\'A} Mayer",
year = "2006",
language = "English",
volume = "27",
pages = "553--560",
journal = "European Journal of Gynaecological Oncology",
issn = "0392-2936",
publisher = "S.O.G. CANADA Inc.",
number = "6",

}

TY - JOUR

T1 - Nerve-sparing radical hysterectomy for Stage IA2-IIB cervical cancer

T2 - 5-Year survival of 501 consecutive cases

AU - Papp, Z.

AU - Csapó, Z.

AU - Hupuczi, P.

AU - Mayer, Á

PY - 2006

Y1 - 2006

N2 - Objective: The purpose of this study was to assess the 5-year survival and morbidity in cases with radical hysterectomy and pelvic lymphadenectomy with pre- and postoperative irradiation performed to treat Stage IA2-IIB cervical cancer. Methods: During a 101/2-year period between July 1990 and December 2000, 501 consecutive radical hysterectomies with bilateral pelvic lymphadenectomy were performed by the same gynecological surgeon in Stage IA2, IB, IIA and IIB cervical cancer. The patients were treated by pre- and postoperative irradiation as well. Results: Apart from recurrence, perioperative complications were minimal with no long-term morbidity. The absolute 5-year survival rates for the patients in Stage IA2, IB1, IB2, IIA and IIB were 94.4%, 90.7%, 84.1%, 71.1%, and 55.4%, respectively. The respective 5-year survival rates for patients without or with lymph node metastasis were 94.5% and 33.3% in Stage IB2, 81.7% and 48.7% in Stage IIA and 70.2% and 36.5% in Stage IIB, respectively. Conclusions: Nerve-sparing radical hysterectomy with pelvic lymph node dissection and pre- and postoperative irradiation remains the treatment of choice for most patients with early-stage and even Stage IIB cervical cancer. The radicalism and extent of lymph node dissection and parametrial resection should be individualized and tailored to tumor- and patient-related risk factors.

AB - Objective: The purpose of this study was to assess the 5-year survival and morbidity in cases with radical hysterectomy and pelvic lymphadenectomy with pre- and postoperative irradiation performed to treat Stage IA2-IIB cervical cancer. Methods: During a 101/2-year period between July 1990 and December 2000, 501 consecutive radical hysterectomies with bilateral pelvic lymphadenectomy were performed by the same gynecological surgeon in Stage IA2, IB, IIA and IIB cervical cancer. The patients were treated by pre- and postoperative irradiation as well. Results: Apart from recurrence, perioperative complications were minimal with no long-term morbidity. The absolute 5-year survival rates for the patients in Stage IA2, IB1, IB2, IIA and IIB were 94.4%, 90.7%, 84.1%, 71.1%, and 55.4%, respectively. The respective 5-year survival rates for patients without or with lymph node metastasis were 94.5% and 33.3% in Stage IB2, 81.7% and 48.7% in Stage IIA and 70.2% and 36.5% in Stage IIB, respectively. Conclusions: Nerve-sparing radical hysterectomy with pelvic lymph node dissection and pre- and postoperative irradiation remains the treatment of choice for most patients with early-stage and even Stage IIB cervical cancer. The radicalism and extent of lymph node dissection and parametrial resection should be individualized and tailored to tumor- and patient-related risk factors.

KW - 5-Year survival

KW - Cervical cancer

KW - Nerve-sparing radical hysterectomy

KW - Pelvic lymphadenectomy

KW - Pre- and postoperative irradiation

KW - Wertheim operation

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M3 - Article

VL - 27

SP - 553

EP - 560

JO - European Journal of Gynaecological Oncology

JF - European Journal of Gynaecological Oncology

SN - 0392-2936

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