Neonatal treatment with monosodium-l-glutamate: Differential effects on growth hormone and prolactin release induced by morphine

Ferenc A. Antoni, Béla Kanyicsk, Éva Mezey, G. Makara

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The aim of this study was to investigate further the possible role of nerve cells of the arcuate nucleus in the regulation of growth hormone (GH) and prolactin (PRL) secretion. Newborn male rats were treated with monosodium-L-glutamate (MSG) (4 g/kg body weight subcutaneously) or NaCl (0.5 g/kg) on alternate days for the first 10 days of life, and were used 8–9 weeks afterwards. β-Endorphin-like immunoreactivity in the arcuate nucleus decreased by 54% after MSG treatment. The dopamine content of the median eminence was reduced to 55% of that in NaCl-treated litter mates. No significant change of dopamine content was found in the other hypothalamic regions examined. Basal levels of plasma PRL were unaltered. Intravenous injection of morphine to urethane-anesthetized animals was 3 times more potent in stimulating PRL secretion in MSG-treated rats, while it was 2.5 times less potent in releasing GH. These data suggest that lesioning of the arcuate nucleus by MSG treatment damages neurons inhibiting PRL secretion, as well as neurons facilitating GH secretion.

Original languageEnglish
Pages (from-to)231-235
Number of pages5
JournalNeuroendocrinology
Volume35
Issue number4
DOIs
Publication statusPublished - 1982

Fingerprint

Sodium Glutamate
Prolactin
Morphine
Arcuate Nucleus of Hypothalamus
Growth Hormone
Glutamic Acid
Neurons
Dopamine
Endorphins
Median Eminence
Urethane
Therapeutics
Cell Nucleus
Intravenous Injections
Body Weight

Keywords

  • Growth hormone
  • Monosodium glutamate
  • Opiates
  • Prolactin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

Neonatal treatment with monosodium-l-glutamate : Differential effects on growth hormone and prolactin release induced by morphine. / Antoni, Ferenc A.; Kanyicsk, Béla; Mezey, Éva; Makara, G.

In: Neuroendocrinology, Vol. 35, No. 4, 1982, p. 231-235.

Research output: Contribution to journalArticle

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