Neonatal PACAP administration in rats delays puberty through the influence of the LHRH neuronal system

F. Szabó, J. Horváth, A. Heinzlmann, A. Arimura, K. Köves

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The onset of puberty is a concerted action of many factors which leads to cyclic LHRH release in rats. It has been demonstrated that; in common with vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase activating polypeptide (PACAP) is also involved in the differentiation of the central nervous system. In our previous work, it was shown that a single PACAP injection into neonatal female rats delayed puberty. In the present work, neonatal administration of PACAP delayed the vaginal opening and decreased the weight of anterior pituitaries, the number of expelled ova at the first ovulation and the intensity of LHRH immunostaining in the septo-preoptico-infundibular system. PACAP antiserum had a reverse effect on LHRH immunoreactivity. The other studied parameters in the latter group remained unchanged compared to control rats. It was concluded that neonatal PACAP administration delayed the onset of puberty through the influence of the LHRH neuronal system.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalRegulatory Peptides
Volume109
Issue number1-3
DOIs
Publication statusPublished - Nov 15 2002

Fingerprint

Pituitary Adenylate Cyclase-Activating Polypeptide
Puberty
Gonadotropin-Releasing Hormone
Rats
Delayed Puberty
Rat control
Vasoactive Intestinal Peptide
Neurology
Ovulation
Ovum
Immune Sera
Central Nervous System
Weights and Measures
Injections

Keywords

  • Image analysis
  • LHRH immunohistochemistry
  • Ovary
  • Ovulation
  • Pituitary

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Neonatal PACAP administration in rats delays puberty through the influence of the LHRH neuronal system. / Szabó, F.; Horváth, J.; Heinzlmann, A.; Arimura, A.; Köves, K.

In: Regulatory Peptides, Vol. 109, No. 1-3, 15.11.2002, p. 49-55.

Research output: Contribution to journalArticle

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