Neonatal maternal deprivation modifies feeding in response to pharmacological and behavioural factors in adult rats

Z. Penke, B. Fernette, C. Nyakas, J. P. Max, A. Burlet

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Neonatal maternal deprivation permanently modifies the hypothalamo-pituitary-adrenal (HPA) axis and other neurobiological and behavioural parameters in rats. The HPA axis plays a central role in the control of feeding, and participates in the anorexigenic action of dexfenfluramine and restraint stress, and in the orexigenic action of a cafeteria diet. Therefore, we investigated whether maternal deprivation modifies feeding responses to these factors. Experimental pups were separated for 24 h from the mother 5 or 14 days after birth. The anorexigenic response to both dexfenfluramine and restraint stress was increased, and body weight as well as subcutaneous adipose tissue gain induced by cafeteria diet was higher in early deprived adult rats. However, these effects were dependent on the time of maternal deprivation. According to our predictions, the feeding response of maternally deprived rats to anorexigenic and orexigenic agents was altered, which is probably partly due to an altered HPA function, but the participation of the serotonergic, the opioid and/or the dopaminergic system cannot be ruled out. Additional studies are needed to detail precisely the neurobiological substrates of modified feeding behaviour of maternally deprived animals. This early stress paradigm altering feeding behaviour could become an interesting model for research into human eating disorders.

Original languageEnglish
Pages (from-to)421-427
Number of pages7
JournalNeuropharmacology
Volume42
Issue number3
DOIs
Publication statusPublished - 2002

Fingerprint

Maternal Deprivation
Dexfenfluramine
Feeding Behavior
Pharmacology
Diet
Subcutaneous Fat
Opioid Analgesics
Body Weight
Mothers
Parturition
Research

Keywords

  • Cafeteria
  • Dexfenfluramine
  • Early stress
  • Food intake
  • Restraint

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Neonatal maternal deprivation modifies feeding in response to pharmacological and behavioural factors in adult rats. / Penke, Z.; Fernette, B.; Nyakas, C.; Max, J. P.; Burlet, A.

In: Neuropharmacology, Vol. 42, No. 3, 2002, p. 421-427.

Research output: Contribution to journalArticle

@article{03f9bbadc69a4e36833843b5d645e148,
title = "Neonatal maternal deprivation modifies feeding in response to pharmacological and behavioural factors in adult rats",
abstract = "Neonatal maternal deprivation permanently modifies the hypothalamo-pituitary-adrenal (HPA) axis and other neurobiological and behavioural parameters in rats. The HPA axis plays a central role in the control of feeding, and participates in the anorexigenic action of dexfenfluramine and restraint stress, and in the orexigenic action of a cafeteria diet. Therefore, we investigated whether maternal deprivation modifies feeding responses to these factors. Experimental pups were separated for 24 h from the mother 5 or 14 days after birth. The anorexigenic response to both dexfenfluramine and restraint stress was increased, and body weight as well as subcutaneous adipose tissue gain induced by cafeteria diet was higher in early deprived adult rats. However, these effects were dependent on the time of maternal deprivation. According to our predictions, the feeding response of maternally deprived rats to anorexigenic and orexigenic agents was altered, which is probably partly due to an altered HPA function, but the participation of the serotonergic, the opioid and/or the dopaminergic system cannot be ruled out. Additional studies are needed to detail precisely the neurobiological substrates of modified feeding behaviour of maternally deprived animals. This early stress paradigm altering feeding behaviour could become an interesting model for research into human eating disorders.",
keywords = "Cafeteria, Dexfenfluramine, Early stress, Food intake, Restraint",
author = "Z. Penke and B. Fernette and C. Nyakas and Max, {J. P.} and A. Burlet",
year = "2002",
doi = "10.1016/S0028-3908(01)00183-6",
language = "English",
volume = "42",
pages = "421--427",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Neonatal maternal deprivation modifies feeding in response to pharmacological and behavioural factors in adult rats

AU - Penke, Z.

AU - Fernette, B.

AU - Nyakas, C.

AU - Max, J. P.

AU - Burlet, A.

PY - 2002

Y1 - 2002

N2 - Neonatal maternal deprivation permanently modifies the hypothalamo-pituitary-adrenal (HPA) axis and other neurobiological and behavioural parameters in rats. The HPA axis plays a central role in the control of feeding, and participates in the anorexigenic action of dexfenfluramine and restraint stress, and in the orexigenic action of a cafeteria diet. Therefore, we investigated whether maternal deprivation modifies feeding responses to these factors. Experimental pups were separated for 24 h from the mother 5 or 14 days after birth. The anorexigenic response to both dexfenfluramine and restraint stress was increased, and body weight as well as subcutaneous adipose tissue gain induced by cafeteria diet was higher in early deprived adult rats. However, these effects were dependent on the time of maternal deprivation. According to our predictions, the feeding response of maternally deprived rats to anorexigenic and orexigenic agents was altered, which is probably partly due to an altered HPA function, but the participation of the serotonergic, the opioid and/or the dopaminergic system cannot be ruled out. Additional studies are needed to detail precisely the neurobiological substrates of modified feeding behaviour of maternally deprived animals. This early stress paradigm altering feeding behaviour could become an interesting model for research into human eating disorders.

AB - Neonatal maternal deprivation permanently modifies the hypothalamo-pituitary-adrenal (HPA) axis and other neurobiological and behavioural parameters in rats. The HPA axis plays a central role in the control of feeding, and participates in the anorexigenic action of dexfenfluramine and restraint stress, and in the orexigenic action of a cafeteria diet. Therefore, we investigated whether maternal deprivation modifies feeding responses to these factors. Experimental pups were separated for 24 h from the mother 5 or 14 days after birth. The anorexigenic response to both dexfenfluramine and restraint stress was increased, and body weight as well as subcutaneous adipose tissue gain induced by cafeteria diet was higher in early deprived adult rats. However, these effects were dependent on the time of maternal deprivation. According to our predictions, the feeding response of maternally deprived rats to anorexigenic and orexigenic agents was altered, which is probably partly due to an altered HPA function, but the participation of the serotonergic, the opioid and/or the dopaminergic system cannot be ruled out. Additional studies are needed to detail precisely the neurobiological substrates of modified feeding behaviour of maternally deprived animals. This early stress paradigm altering feeding behaviour could become an interesting model for research into human eating disorders.

KW - Cafeteria

KW - Dexfenfluramine

KW - Early stress

KW - Food intake

KW - Restraint

UR - http://www.scopus.com/inward/record.url?scp=0036124487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036124487&partnerID=8YFLogxK

U2 - 10.1016/S0028-3908(01)00183-6

DO - 10.1016/S0028-3908(01)00183-6

M3 - Article

VL - 42

SP - 421

EP - 427

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

IS - 3

ER -