Neocortical cytopathology in focal aminopyridine seizures as related to the intracortical diffusion of [3H] 4-aminopyridine - Electrophysiologic and light-microscopic studies

A. Mihály, G. Tóth, M. Szente, F. Joó

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7 Citations (Scopus)

Abstract

Focal seizure was induced in rat and cat neocortex by the topical application of aminopyridines. The epileptic character of the focal events was followed by surface and intracellular recordings of seizure activity. The pathologic alterations in the neurons, the glial cells, and the protein permeability of the neocortical blood vessels were investigated by means of light microscopy, using standard histological stainings and immunohistochemical detection of endogenous serum albumin. Diffusion of [3H] 4-aminopyridine in the neocortex was studied by light-microscopic autoradiography. The spreading of the neuropathologic changes strictly followed the diffusion of the tritiated compound, suggesting the gradual involvement of neocortical layers in the seizure process.

Original languageEnglish
Pages (from-to)145-154
Number of pages10
JournalActa neuropathologica
Volume66
Issue number2
DOIs
Publication statusPublished - Jun 1 1985

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Keywords

  • Aminopyridines
  • Autoradiography
  • Electrophysiology
  • Epilepsy
  • Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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