Neighboring amide group participation in ester aminolysis in aprotic solvents

T. Kőmives, A. F. Márton, F. Dutka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The piperidinolysis of 8-quinolyl-, p-nitrophenyl-, o-, and p-piperidinocarbonylphenyl acetates in acetonitrile and in chlorobenzene was studied at 25°C. The strictly second order kinetic behaviour and the weaks solvent-dependence of the rate of the reaction of o-piperidinocarbonylphenyl acetate indicate anchimeric assistance by the o-amide group, and support the suggestion that amide groups of hydrophobic enzyme active sites may act as general base catalysts.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalReaction Kinetics and Catalysis Letters
Volume4
Issue number1
DOIs
Publication statusPublished - Mar 1976

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry

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