Nectin-1 (HveC) is expressed at high levels in neural subtypes that regulate radial migration of cortical and cerebellar neurons of the developing human and murine brain

Emese Prandovszky, Szatmár Horváth, Levente Gellért, S. Krisztián Kovács, Z. Janka, J. Toldi, Deepak Shukla, Tibor Vályi-Nagy

Research output: Contribution to journalArticle

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Abstract

Herpes simplex viruses (HSV) produce age-dependent encephalitis characterized by more severe involvement of the cerebral cortex in younger hosts. To elucidate the potential role of the major neural entry receptor of HSV, nectin-1, in age-dependent susceptibility of cortical neurons to viral encephalitis, the authors examined the anatomical distribution of the receptor protein in the developing human and mouse cerebral cortex, hippocampus, and cerebellum by immunohistochemistry. Nectin-1 is expressed at high levels in guiding cells (radial glial cells and Cajal-Retzius cells) that regulate radial migration of neurons in cortical lamination, at lower levels in migrating neurons, and at variable levels in the transient ventricular and marginal zones of the cerebral cortical wall. These results may have implications regarding the selective spatiotemporal tropism of HSV to specific neuronal populations, and for the better understanding of neurodevelopmental defects caused by fetal HSV infections.

Original languageEnglish
Pages (from-to)164-172
Number of pages9
JournalJournal of NeuroVirology
Volume14
Issue number2
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Simplexvirus
Neurons
Cerebral Cortex
Brain
Viral Encephalitis
Ependymoglial Cells
Tropism
Human Herpesvirus 1
Sensory Receptor Cells
Virus Diseases
Encephalitis
Cerebellum
Hippocampus
Immunohistochemistry
Population
nectins
Proteins

Keywords

  • Cajal-Retzius cell
  • Herpes encephalitis
  • Neurotropism
  • Radial glia
  • Susceptibility

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Nectin-1 (HveC) is expressed at high levels in neural subtypes that regulate radial migration of cortical and cerebellar neurons of the developing human and murine brain. / Prandovszky, Emese; Horváth, Szatmár; Gellért, Levente; Kovács, S. Krisztián; Janka, Z.; Toldi, J.; Shukla, Deepak; Vályi-Nagy, Tibor.

In: Journal of NeuroVirology, Vol. 14, No. 2, 03.2008, p. 164-172.

Research output: Contribution to journalArticle

Prandovszky, Emese ; Horváth, Szatmár ; Gellért, Levente ; Kovács, S. Krisztián ; Janka, Z. ; Toldi, J. ; Shukla, Deepak ; Vályi-Nagy, Tibor. / Nectin-1 (HveC) is expressed at high levels in neural subtypes that regulate radial migration of cortical and cerebellar neurons of the developing human and murine brain. In: Journal of NeuroVirology. 2008 ; Vol. 14, No. 2. pp. 164-172.
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