Necrolytic migratory erythema

Réka K. Kovács, Irma Korom, A. Dobozy, Gyula Farkas, Jenõ Ormos, L. Kemény

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Necrolytic migratory erythema is considered to be a paraneoplastic dermatosis. The classical symptoms are associated with α-cell pancreatic islet cell tumor or 'glucagonoma'. Generally, extracutaneous hallmarks of this disease include weight loss, diabetes, anaemia and diarrhoea. Observation: We report a case of a 39-year-old woman with a 3-year history of recalcitrant psoriasiform eruption, who had no other associated symptoms on routine examination. Histologic examinations suggested necrolytic migratory erythema. Abdominal computer tomography was performed, which revealed a tumor in the tail of the pancreas. After distal resection of the pancreas her skin symptoms resolved in a few days time. Histology was consistent with glucagonoma. She is clinically well and symptomless and no signs of metastasis after 4 years. Conclusions: It is infrequent to have only necrolytic migratory erythema, hyperglucagonaemia and islet-cell tumor but no other extracutaneous symptoms in glucagonoma syndrome. To our knowledge, ours is the second such case reported in the literature. Skin symptoms are important, often they are the clue to the diagnosis of glucagonoma syndrome.

Original languageEnglish
Pages (from-to)242-245
Number of pages4
JournalJournal of Cutaneous Pathology
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 2006

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Necrolytic Migratory Erythema
Glucagonoma
Pancreas
Islet Cell Adenoma
Skin
Skin Diseases
Anemia
Weight Loss
Diarrhea
Histology
Tomography
Observation
Neoplasm Metastasis
Neoplasms

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Necrolytic migratory erythema. / Kovács, Réka K.; Korom, Irma; Dobozy, A.; Farkas, Gyula; Ormos, Jenõ; Kemény, L.

In: Journal of Cutaneous Pathology, Vol. 33, No. 3, 03.2006, p. 242-245.

Research output: Contribution to journalArticle

Kovács, Réka K. ; Korom, Irma ; Dobozy, A. ; Farkas, Gyula ; Ormos, Jenõ ; Kemény, L. / Necrolytic migratory erythema. In: Journal of Cutaneous Pathology. 2006 ; Vol. 33, No. 3. pp. 242-245.
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