Necrobiosis lipoidica diabetes mellitus nélkül (diagnosztikus és terápiás lehetöségek).

Translated title of the contribution: Necrobiosis lipoidica without diabetes mellitus (diagnostic and therapeutic possibilities)

A. Császár, J. Daróczy, P. Szénási, L. Anda, L. Tóth, N. Hosszúfalusi, I. Karádi, L. Kalabay, L. Romics

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The goal of the present study was to follow the clinical behaviour of 6 non diabetic patients (5 females and 1 male, aged 23-68) suffering from necrobiosis lipoidica. Thickening of the basalmembrane of capillaries could be confirmed by electron microscopy, although the histological structure of skin alterations are not different from those observed in diabetes mellitus. Three patients (2 females and one male) showed impaired glucose tolerance, 2 other patients had increased levels of total cholesterol, whereas one patient suffered from both metabolic disturbances. After treatment with ASA (acetylsalicylic acid, 1.0 g/day) and dipyridamole (200 mg/day) for six weeks, the decrease of platelet in vitro aggregation in platelet rich plasma could be observed by stimulation with arachidonic acid, epinephrine, ADP and collagen, respectively. Healing of the exulceration of skin lesion could be detected by the use of the combined treatment of ASA and dipyridamole in 4 cases.

Original languageHungarian
Pages (from-to)2141-2145
Number of pages5
JournalOrvosi Hetilap
Volume130
Issue number40
Publication statusPublished - Oct 1 1989

Fingerprint

Necrobiosis Lipoidica
Diabetes Mellitus
Dipyridamole
Skin
Platelet-Rich Plasma
Glucose Intolerance
Therapeutics
Arachidonic Acid
Adenosine Diphosphate
Epinephrine
Aspirin
Electron Microscopy
Collagen
Blood Platelets
Cholesterol

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Császár, A., Daróczy, J., Szénási, P., Anda, L., Tóth, L., Hosszúfalusi, N., ... Romics, L. (1989). Necrobiosis lipoidica diabetes mellitus nélkül (diagnosztikus és terápiás lehetöségek). Orvosi Hetilap, 130(40), 2141-2145.

Necrobiosis lipoidica diabetes mellitus nélkül (diagnosztikus és terápiás lehetöségek). / Császár, A.; Daróczy, J.; Szénási, P.; Anda, L.; Tóth, L.; Hosszúfalusi, N.; Karádi, I.; Kalabay, L.; Romics, L.

In: Orvosi Hetilap, Vol. 130, No. 40, 01.10.1989, p. 2141-2145.

Research output: Contribution to journalArticle

Császár, A. ; Daróczy, J. ; Szénási, P. ; Anda, L. ; Tóth, L. ; Hosszúfalusi, N. ; Karádi, I. ; Kalabay, L. ; Romics, L. / Necrobiosis lipoidica diabetes mellitus nélkül (diagnosztikus és terápiás lehetöségek). In: Orvosi Hetilap. 1989 ; Vol. 130, No. 40. pp. 2141-2145.
@article{9260e4d013574216938235b028d3e12d,
title = "Necrobiosis lipoidica diabetes mellitus n{\'e}lk{\"u}l (diagnosztikus {\'e}s ter{\'a}pi{\'a}s lehet{\"o}s{\'e}gek).",
abstract = "The goal of the present study was to follow the clinical behaviour of 6 non diabetic patients (5 females and 1 male, aged 23-68) suffering from necrobiosis lipoidica. Thickening of the basalmembrane of capillaries could be confirmed by electron microscopy, although the histological structure of skin alterations are not different from those observed in diabetes mellitus. Three patients (2 females and one male) showed impaired glucose tolerance, 2 other patients had increased levels of total cholesterol, whereas one patient suffered from both metabolic disturbances. After treatment with ASA (acetylsalicylic acid, 1.0 g/day) and dipyridamole (200 mg/day) for six weeks, the decrease of platelet in vitro aggregation in platelet rich plasma could be observed by stimulation with arachidonic acid, epinephrine, ADP and collagen, respectively. Healing of the exulceration of skin lesion could be detected by the use of the combined treatment of ASA and dipyridamole in 4 cases.",
author = "A. Cs{\'a}sz{\'a}r and J. Dar{\'o}czy and P. Sz{\'e}n{\'a}si and L. Anda and L. T{\'o}th and N. Hossz{\'u}falusi and I. Kar{\'a}di and L. Kalabay and L. Romics",
year = "1989",
month = "10",
day = "1",
language = "Hungarian",
volume = "130",
pages = "2141--2145",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "40",

}

TY - JOUR

T1 - Necrobiosis lipoidica diabetes mellitus nélkül (diagnosztikus és terápiás lehetöségek).

AU - Császár, A.

AU - Daróczy, J.

AU - Szénási, P.

AU - Anda, L.

AU - Tóth, L.

AU - Hosszúfalusi, N.

AU - Karádi, I.

AU - Kalabay, L.

AU - Romics, L.

PY - 1989/10/1

Y1 - 1989/10/1

N2 - The goal of the present study was to follow the clinical behaviour of 6 non diabetic patients (5 females and 1 male, aged 23-68) suffering from necrobiosis lipoidica. Thickening of the basalmembrane of capillaries could be confirmed by electron microscopy, although the histological structure of skin alterations are not different from those observed in diabetes mellitus. Three patients (2 females and one male) showed impaired glucose tolerance, 2 other patients had increased levels of total cholesterol, whereas one patient suffered from both metabolic disturbances. After treatment with ASA (acetylsalicylic acid, 1.0 g/day) and dipyridamole (200 mg/day) for six weeks, the decrease of platelet in vitro aggregation in platelet rich plasma could be observed by stimulation with arachidonic acid, epinephrine, ADP and collagen, respectively. Healing of the exulceration of skin lesion could be detected by the use of the combined treatment of ASA and dipyridamole in 4 cases.

AB - The goal of the present study was to follow the clinical behaviour of 6 non diabetic patients (5 females and 1 male, aged 23-68) suffering from necrobiosis lipoidica. Thickening of the basalmembrane of capillaries could be confirmed by electron microscopy, although the histological structure of skin alterations are not different from those observed in diabetes mellitus. Three patients (2 females and one male) showed impaired glucose tolerance, 2 other patients had increased levels of total cholesterol, whereas one patient suffered from both metabolic disturbances. After treatment with ASA (acetylsalicylic acid, 1.0 g/day) and dipyridamole (200 mg/day) for six weeks, the decrease of platelet in vitro aggregation in platelet rich plasma could be observed by stimulation with arachidonic acid, epinephrine, ADP and collagen, respectively. Healing of the exulceration of skin lesion could be detected by the use of the combined treatment of ASA and dipyridamole in 4 cases.

UR - http://www.scopus.com/inward/record.url?scp=0024747284&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024747284&partnerID=8YFLogxK

M3 - Article

VL - 130

SP - 2141

EP - 2145

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 40

ER -