Nature of gastric H+ backdiffusion approached by cimetidine, vagotomy resiniferatoxin (RTX) and sucralfate

O. M E Abdel-Salam, B. Bodis, O. Karadi, J. Szolcsányi, G. Mózsik

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The role of capsacain-sensitive sensory nerves (CSSN) in monitoring gastric acid backdiffusion is disenssed. We investigated the effect of subcutaneous (sc) cimetidine and intragastric (ig) sucralfate on H+ back-diffusion in stomachs of pyloric-ligated rats exposed to HCl (2 ml of 0.15 N) or acidified salicylate (200 mg/kg in 2 ml of 0.15 N HCl) and the possible modification of their action by stimulation of CSSN (with the i.g. administered capsacain analogue resiniferatoxin) under conditions of intact vagus nerve and after surgical vagotomy. Cimetidine did not modify the extent of H+ backdiffusion caused by acidified salicylate, while resiniferation (RTX) as well as sucralfate decreased it. In vitro sucralfate was found to adsorb H+ when incubated with HCl. The gastroprotective effect of cimetidine and sucralfate were not evident after surgical vagotomy. We conclude that RTX and sucralfate are able to reduce gastric H+ backdiffusion. The vagus nerve is necessary for the gastroprotective affect of cimetidine and sucralfate.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalCeska a Slovenska Gastroenterologie
Volume49
Issue number5
Publication statusPublished - 1995

Fingerprint

Sucralfate
Vagotomy
Cimetidine
Stomach
Vagus Nerve
Salicylates
Gastric Acid
resiniferatoxin

Keywords

  • Cimetidine
  • Gastric H backdiffusion
  • Resiniferatoxin
  • Sucralfate
  • Surgical vagotomy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Nature of gastric H+ backdiffusion approached by cimetidine, vagotomy resiniferatoxin (RTX) and sucralfate. / Abdel-Salam, O. M E; Bodis, B.; Karadi, O.; Szolcsányi, J.; Mózsik, G.

In: Ceska a Slovenska Gastroenterologie, Vol. 49, No. 5, 1995, p. 175-182.

Research output: Contribution to journalArticle

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