Natural selection promotes the conservation of linkage of co-expressed genes

Laurence D. Hurst, Elizabeth J B Williams, C. Pál

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Although there is increasing evidence that eukaryotic gene order is not always random, there is no evidence that putatively favourable gene arrangements are preserved by selection more than expected by chance. In yeast (Saccharomyces cerevisiae), for example, co-expressed genes tend to be linked, but whether such gene pairs tend to remain linked more often than expected under null neutral expectations is not known. We show using gene pairs in the S. cerevisiae-Candida albicans comparison that highly co-expressed gene pairs are conserved as pairs at about twice the average rate. However, co-expressed genes also tend to be in close physical proximity and, as expected from a null neutral model, genes (be they co-expressed or not) that are physically close together tend to be retained more often. This physical proximity, however, only accounts for a small proportion of the enhanced degree of conservation of co-expressed gene pairs. These results demonstrate that purely neutralist models of gene order evolution are not realistic.

Original languageEnglish
Pages (from-to)604-606
Number of pages3
JournalTrends in Genetics
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 1 2002

Fingerprint

Genetic Selection
Gene Order
Genes
Saccharomyces cerevisiae
Candida albicans
Yeasts

ASJC Scopus subject areas

  • Genetics

Cite this

Natural selection promotes the conservation of linkage of co-expressed genes. / Hurst, Laurence D.; Williams, Elizabeth J B; Pál, C.

In: Trends in Genetics, Vol. 18, No. 12, 01.12.2002, p. 604-606.

Research output: Contribution to journalArticle

Hurst, Laurence D. ; Williams, Elizabeth J B ; Pál, C. / Natural selection promotes the conservation of linkage of co-expressed genes. In: Trends in Genetics. 2002 ; Vol. 18, No. 12. pp. 604-606.
@article{7af78c33418e4d6984047e51900d6eff,
title = "Natural selection promotes the conservation of linkage of co-expressed genes",
abstract = "Although there is increasing evidence that eukaryotic gene order is not always random, there is no evidence that putatively favourable gene arrangements are preserved by selection more than expected by chance. In yeast (Saccharomyces cerevisiae), for example, co-expressed genes tend to be linked, but whether such gene pairs tend to remain linked more often than expected under null neutral expectations is not known. We show using gene pairs in the S. cerevisiae-Candida albicans comparison that highly co-expressed gene pairs are conserved as pairs at about twice the average rate. However, co-expressed genes also tend to be in close physical proximity and, as expected from a null neutral model, genes (be they co-expressed or not) that are physically close together tend to be retained more often. This physical proximity, however, only accounts for a small proportion of the enhanced degree of conservation of co-expressed gene pairs. These results demonstrate that purely neutralist models of gene order evolution are not realistic.",
author = "Hurst, {Laurence D.} and Williams, {Elizabeth J B} and C. P{\'a}l",
year = "2002",
month = "12",
day = "1",
doi = "10.1016/S0168-9525(02)02813-5",
language = "English",
volume = "18",
pages = "604--606",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "Elsevier Limited",
number = "12",

}

TY - JOUR

T1 - Natural selection promotes the conservation of linkage of co-expressed genes

AU - Hurst, Laurence D.

AU - Williams, Elizabeth J B

AU - Pál, C.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Although there is increasing evidence that eukaryotic gene order is not always random, there is no evidence that putatively favourable gene arrangements are preserved by selection more than expected by chance. In yeast (Saccharomyces cerevisiae), for example, co-expressed genes tend to be linked, but whether such gene pairs tend to remain linked more often than expected under null neutral expectations is not known. We show using gene pairs in the S. cerevisiae-Candida albicans comparison that highly co-expressed gene pairs are conserved as pairs at about twice the average rate. However, co-expressed genes also tend to be in close physical proximity and, as expected from a null neutral model, genes (be they co-expressed or not) that are physically close together tend to be retained more often. This physical proximity, however, only accounts for a small proportion of the enhanced degree of conservation of co-expressed gene pairs. These results demonstrate that purely neutralist models of gene order evolution are not realistic.

AB - Although there is increasing evidence that eukaryotic gene order is not always random, there is no evidence that putatively favourable gene arrangements are preserved by selection more than expected by chance. In yeast (Saccharomyces cerevisiae), for example, co-expressed genes tend to be linked, but whether such gene pairs tend to remain linked more often than expected under null neutral expectations is not known. We show using gene pairs in the S. cerevisiae-Candida albicans comparison that highly co-expressed gene pairs are conserved as pairs at about twice the average rate. However, co-expressed genes also tend to be in close physical proximity and, as expected from a null neutral model, genes (be they co-expressed or not) that are physically close together tend to be retained more often. This physical proximity, however, only accounts for a small proportion of the enhanced degree of conservation of co-expressed gene pairs. These results demonstrate that purely neutralist models of gene order evolution are not realistic.

UR - http://www.scopus.com/inward/record.url?scp=0036890388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036890388&partnerID=8YFLogxK

U2 - 10.1016/S0168-9525(02)02813-5

DO - 10.1016/S0168-9525(02)02813-5

M3 - Article

VL - 18

SP - 604

EP - 606

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 12

ER -