Natural roles of antimicrobial peptides in microbes, plants and animals

G. Maróti Gergely, Attila Kereszt, Éva Kondorosi, Peter Mergaert

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Antimicrobial peptides (AMPs) are ribosomally synthesized natural antibiotics that are crucial effectors of innate immune systems in all living organisms. AMPs are diverse peptides, differing in their amino acid composition and structure, that generally display rapid killing and broad-spectrum antimicrobial activities. Therefore, AMPs have high potential for therapeutic use in healthcare and agriculture. This review focuses on in vivo studies relating how organisms - bacteria, plants, insects and mammals - employ AMPs in their interactions with microbial competitors, pathogens and symbionts.

Original languageEnglish
Pages (from-to)363-374
Number of pages12
JournalResearch in Microbiology
Volume162
Issue number4
DOIs
Publication statusPublished - May 1 2011

Keywords

  • Antimicrobial peptides
  • Defensin
  • Innate immunity
  • Pathogen
  • Resistance
  • Symbiosis

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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