Natural lymphocyte cytotoxicity of women with different symptoms of toxemia

P. Varga, W. Günther, A. Bolte, J. Szekeres-Bartho

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Natural cytotoxic activity of lymphocytes from 113 pregnant women presenting one or more symptoms of the toxemic triad (E, P or H) was tested. According to the clinical symptoms, groups EH + H, EP + P and PH + EPH were formed. The control group consisted of 56 healthy pregnant patients. Significantly increased cytotoxicity was observed in toxemic pregnancies with proteinuria (group EP + P, 35.8 ± 14.3%, P < 0.001) and with proteinuria and hypertension (group PH + EPH, 27.2 ± 13.3%, P < 0.001%), but not in the group with hypertension (EH + H, 13.0 + 9.9%), compared to that of controls (11.0 + 11.5%). The relative number of patients with cytotoxicity ≥ 40% was also higher in groups with proteinuria presenting with or without other symptoms of the disease. Increased cytotoxicity in proteinuric form of gestosis seemed to be independent of the incidence of low birthweight deliveries and intra-uterine growth retardation.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number2
Publication statusPublished - Apr 16 1991



  • Lymphocyte cytotoxicity
  • Pre-eclampsia
  • Toxemia of pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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