Natural history of ulcerative colitis

Current knowledge

Lajos Sandor Kiss, P. Lakatos

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The clinical presentation at the time of diagnosis and the disease course of ulcerative colitis (UC) are heterogeneous and variable over time. In population-based epidemiological follow-up studies from the last decades, the extent of UC has shown only slight variation. At diagnosis, the initial extent is evenly distributed among proctitis, leftsided, and extensive colitis with some exceptions. The disease course may vary from a single attack to chronic symptoms that reduce the quality of life as well as lead to disease extension, colectomy or even to the development of colitisassociated colorectal cancer in some cases. Important predictive clinical factors and biomarkers of disease course have been under increasing scrutiny. Those identified may eventually lead to a more personalized, tailored therapy. In this review article, the authors summarize the available evidence on the natural history and predictive markers for evaluating the course of UC.

Original languageEnglish
Pages (from-to)1390-1395
Number of pages6
JournalCurrent Drug Targets
Volume12
Issue number10
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Ulcerative Colitis
Proctitis
Colectomy
Biomarkers
Colitis
Natural History
Colorectal Neoplasms
Quality of Life
Population
Therapeutics

Keywords

  • Natural history
  • Predictive factors
  • UC-CRC
  • Ulcerative colitis

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Natural history of ulcerative colitis : Current knowledge. / Kiss, Lajos Sandor; Lakatos, P.

In: Current Drug Targets, Vol. 12, No. 10, 09.2011, p. 1390-1395.

Research output: Contribution to journalArticle

Kiss, Lajos Sandor ; Lakatos, P. / Natural history of ulcerative colitis : Current knowledge. In: Current Drug Targets. 2011 ; Vol. 12, No. 10. pp. 1390-1395.
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