Natriuresis of fasting: The possible role of leptin-neuropeptide Y system

Research output: Contribution to journalArticle

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Abstract

We developed a new hypothesis claiming that natriuresis of fasting is not only caused by diminished insulin resistance and hyperinsulinaemia with the subsequent reduction of renal sodium retention but it can also be attributed to the function of the leptin-NPY system. Each element of this concept has been substantiated by convincing experimental evidences as follows: 1. Leptin, the adipocyte-derived peptide hormone conveys information to the central nervous system about the size of body energy stores and it reciprocally regulates the hypothalamic expression of NPY, the major mediator of its metabolic and neuroendocrine actions. 2. NPY has been demonstrated to be intimately involved in the regulation of renal functions; under various experimental conditions it increased urine flow rate and urinary sodium excretion presumably through stimulating the synthesis and/or release of other natriuretic factors. 3. Fasting-induced suppression of tissue expression of leptin mRNA and circulating plasma leptin levels is associated with simultaneous activation of NPY system. 4. This sequence of events implies that NPY contributes to natriuresis that occurs in response to fasting.

Original languageEnglish
Pages (from-to)629-633
Number of pages5
JournalMedical Hypotheses
Volume56
Issue number5
DOIs
Publication statusPublished - 2001

Fingerprint

Natriuresis
Neuropeptide Y
Leptin
Fasting
Sodium
Natriuretic Agents
Kidney
Peptide Hormones
Hyperinsulinism
Body Size
Adipocytes
Insulin Resistance
Central Nervous System
Urine
Messenger RNA

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Natriuresis of fasting : The possible role of leptin-neuropeptide Y system. / Sulyok, E.; Tulassay, T.

In: Medical Hypotheses, Vol. 56, No. 5, 2001, p. 629-633.

Research output: Contribution to journalArticle

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