Nationwide investigation of multiple malformations

E. Czeizel, P. Kiss, M. Osztovics, I. Pazonyi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A nationwide programme for the evaluation of 1,339 newborns with multiple malformations (about 8% of all malformed babies) notified to the Hungarian Congenital Malformation Registry in the period 1973 to 1975, was launched on January 1st, 1973. As specific syndromes and anomalies, 696 cases (51.9%) were notified. On the basis of individual malformations, 87 cases were identified from 439 patients with notified associations, and 27 multiple malformations among 172 stillborns and infant deaths were recognized from autopsy records collected from pathologists. 341 surviving infants were officially referred to 'multiple malformation centers' for special examination. 57 infants of 129 cooperating families were identified. Benefits of this programme are: the proportion of specific syndromes and anomalies, increased by 12.8%; the rate of unspecified multiple malformations decreased by 56.6%; examination of multiple malformations may be the most sensitive means to detect teratogens; 50.5% of the expected number of chromosome abnormalities in newborns was found; and the nationwide material of multiple malformed babies offers a possibility to clarify gene abnormalities and new syndromes.

Original languageEnglish
Pages (from-to)275-280
Number of pages6
JournalActa Paediatrica Academiae Scientiarum Hungaricae
Volume19
Issue number4
Publication statusPublished - 1978

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Newborn Infant
Teratogens
Program Evaluation
Chromosome Aberrations
Registries
Autopsy
Genes
Pathologists
Infant Death

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nationwide investigation of multiple malformations. / Czeizel, E.; Kiss, P.; Osztovics, M.; Pazonyi, I.

In: Acta Paediatrica Academiae Scientiarum Hungaricae, Vol. 19, No. 4, 1978, p. 275-280.

Research output: Contribution to journalArticle

Czeizel, E, Kiss, P, Osztovics, M & Pazonyi, I 1978, 'Nationwide investigation of multiple malformations', Acta Paediatrica Academiae Scientiarum Hungaricae, vol. 19, no. 4, pp. 275-280.
Czeizel, E. ; Kiss, P. ; Osztovics, M. ; Pazonyi, I. / Nationwide investigation of multiple malformations. In: Acta Paediatrica Academiae Scientiarum Hungaricae. 1978 ; Vol. 19, No. 4. pp. 275-280.
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