National programme for prevention of the recurrence of neural tube defects

A. Czeizel, L. Kerekes, K. Meretey, M. Osztovics, M. Sobel, A. Stuber, S. Tarró

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Abstract

Mothers who since 1970 gave birth to children with anencephaly or spina bifida in Hungary are informed about the recurrence risk, the possibility of prevention and about the four institutes where amniotic alpha-feto-protein determination is done. In one of these institutes the examination was recommended to 175 women of whom 158 availed themselves of the opportunity. The outcome of their pregnancy is not known in 131 cases. Of these, in 101 the examination was performed because of previous occurrence of anencephaly-spina bifida. High concentrations (400, 200, 140 μg/ml) were found in 3 cases; they were due to anencephaly (selective induced abortion), severe spina bifida (liveborn) and macerated fetal death. The examination yielded values above the 99% confidence limit in the given gestational week in 9 further cases. The elevated values were due to twinning in 2 cases, to closed spina bifida in 1, and to fetal death in 1 case. The slightly elevated alpha-fetoprotein in 4 of them may have been due to chance.

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalActa paediatrica Academiae Scientiarum Hungaricae
Volume20
Issue number4
Publication statusPublished - Dec 1 1979

ASJC Scopus subject areas

  • Medicine(all)

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    Czeizel, A., Kerekes, L., Meretey, K., Osztovics, M., Sobel, M., Stuber, A., & Tarró, S. (1979). National programme for prevention of the recurrence of neural tube defects. Acta paediatrica Academiae Scientiarum Hungaricae, 20(4), 315-319.