Nasal carriage of Streptococcus pneumoniae among Hungarian children before the wide use of the conjugate vaccine

Adrienn Tóthpál, Szilvia Kardos, Edit Hajdú, Károly Nagy, Mark Linden, Orsolya Dobay

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Streptococcus pneumoniae is responsible for a significant amount of morbidity and mortality worldwide, especially among children <5 years. Healthy carriers are the most important sources of infections and the carriage also peaks in the first years of life, especially among children attending communities. In this study, for the first time in Hungary, we surveyed the nasal carriage of healthy children, just before the use of the conjugate vaccine started increasing.Nasal specimens of 358 children were cultured and pneumococci isolated. The strains were serotyped with antisera and PCR, genotyped by PFGE and their antibiotic sensitivity determined by agar dilution method.The carriage rate was 37.71%. The isolates were sensitive to most tested antibiotics, except for macrolides. In this cohort of specimens still the widespread, so-called "pediatric serotypes" dominated (14, 19F, 23F, 6A, 6B in ranking order), but three of the previously rare types: 15B, 11A and 13 were represented already by 21.5% of all strains and also a few other rare non-vaccine types (e.g. 10A or 37) were detected.The calculated vaccine coverage was 55.6% for PCV-7, 69.6% for PCV-13 and 86.7% for Pneumovax. In this cohort, only 15.9% of the children (n = 57) were vaccinated. The carriage rate of PCV-7 vaccinated children was significantly lower (30.4%) than that of the non-vaccinated group (39.2%). The clonality of the isolates was significant within each group, revealing the extensive bacterium exchange among children.

Original languageEnglish
Pages (from-to)107-118
Number of pages12
JournalActa microbiologica et immunologica Hungarica
Volume59
Issue number1
DOIs
Publication statusPublished - Mar 1 2012

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Keywords

  • Pneumococcus
  • conjugate vaccine
  • day-care centres
  • epidemiology
  • serotypes
  • vaccine coverage

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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