Narrow-band UVB phototherapy of nasal polyps

Results of a pilot study

Zsolt Bella, Edit Kadocsa, L. Kemény, A. Koreck

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Nasal polyposis (NP) is characterized by high recurrence rate despite medical and/or surgical treatment. The major mechanism of action of ultraviolet B light (UVB) is induction of apoptosis in inflammatory cells. Therefore phototherapy may represent a new therapeutic approach in NP.A pilot feasibility study was performed to assess the tolerability and clinical efficacy of UVB phototherapy in NP. Thirteen subjects with bilateral grade 1-3 NP were enrolled in an open-labeled prospective pilot study. Patients were exposed to gradually increasing doses of UVB light over a 12. week period (3 exposures/week). Subjects rated their nasal obstruction symptom scores weekly on a visual analogue scale from 0 to 6. The NOSE quality of life questionnaire was used at baseline and end of treatment period. Adverse events were monitored by endoscopy. Ten subjects completed the study. Nasal obstruction symptom scores and quality of life (NOSE) improved at end of treatment compared to baseline. Treatments were well tolerated and no device related adverse events were reported. The results suggest that phototherapy may represent a potential new treatment option in nasal polyps.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalJournal of Photochemistry and Photobiology, B: Biology
Volume100
Issue number3
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Nasal Polyps
Phototherapy
Ultraviolet Rays
narrowband
Nose
Nasal Obstruction
Therapeutics
Quality of Life
apoptosis
Feasibility Studies
grade
Visual Analog Scale
induction
Endoscopy
analogs
dosage
Prospective Studies
Light
Recurrence
Equipment and Supplies

Keywords

  • Nasal polyposis
  • Phototherapy
  • UVB light

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics
  • Medicine(all)

Cite this

Narrow-band UVB phototherapy of nasal polyps : Results of a pilot study. / Bella, Zsolt; Kadocsa, Edit; Kemény, L.; Koreck, A.

In: Journal of Photochemistry and Photobiology, B: Biology, Vol. 100, No. 3, 09.2010, p. 123-127.

Research output: Contribution to journalArticle

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