Nanoparticles prepared by self-assembly of chitosan and poly-y-glutamic acid

M. Bodnar, I. Hajdu, G. Filipcsei, L. Daroczi, J. F. Hartmann, J. Borbely

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The present investigation reports the formation of stable polyelectrolyte complexes of poly-gamma-glutamic acid (γPGA) and chitosan (Chit) by self-assembly in aqueous media at room temperature. The solubility and size of these nanoparticles in the dried and swollen states will be described and discussed. The correlation of size of particles, pH of the solutions, concentration, order of addition and the ratio of compound polyelectrolytes have been studied. It was found, that the size and size distribution of the nanosystems depends on the concentrations of γPGA and Chit solutions and their ratio as well as on the pH of the mixture and the order of addition. The diameter of individual particles was in the range of 40-285 nm measured by TEM, and the average hydrodynamic diameters were between 80-200 nm. These biodegradable, self-assembled stable nanocomplexes might be useful for several biomedical applications.

Original languageEnglish
Title of host publication2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Pages143-146
Number of pages4
Publication statusPublished - Aug 23 2007
Event2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, CA, United States
Duration: May 20 2007May 24 2007

Publication series

Name2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Volume2

Other

Other2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
CountryUnited States
CitySanta Clara, CA
Period5/20/075/24/07

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Keywords

  • Chitosan
  • Nanoparticles
  • Poly-γ-glutamic acid
  • Polyelectrolyte
  • Self-assembly

ASJC Scopus subject areas

  • Mechanical Engineering

Cite this

Bodnar, M., Hajdu, I., Filipcsei, G., Daroczi, L., Hartmann, J. F., & Borbely, J. (2007). Nanoparticles prepared by self-assembly of chitosan and poly-y-glutamic acid. In 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings (pp. 143-146). (2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings; Vol. 2).