Nanofibrous solid dosage form of living bacteria prepared by electrospinning

Zs K. Nagy, I. Wagner, Á Suhajda, T. Tobak, A. H. Harasztos, T. Vigh, P. L. Sóti, H. Pataki, K. Molnár, G. Marosi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The aim of this work was to investigate the suitability of electrospinning for biodrug delivery and to develop an electrospinning-based method to produce vaginal drug delivery systems. Lactobacillus acidophilus bacteria were encapsulated into nanofibers of three different polymers (polyvinyl alcohol and polyvinylpyrrolidone with two different molar masses). Shelf life of the bacteria could be enhanced by the exclusion of water and by preparing a solid dosage form, which is an advantageous and patient-friendly way of administration. The formulations were stored at -20, 7 and 25°C, respectively. Viability testing showed that the nanofibers can provide long term stability for huge amounts of living bacteria if they are kept at (or below) 7°C. Furthermore, all kinds of nanowebs prepared in this work dissolved instantly when they got in contact with water, thus the developed biohybrid nanowebs can provide new potential ways for curing bacterial vaginosis.

Original languageEnglish
Pages (from-to)352-361
Number of pages10
JournalExpress Polymer Letters
Volume8
Issue number5
DOIs
Publication statusPublished - May 2014

Fingerprint

Dosage Forms
Electrospinning
bacteria
Bacteria
Nanofibers
dosage
delivery
Polyvinyl Alcohol
Povidone
Water
Molar mass
polyvinyl alcohol
Polyvinyl alcohols
curing
exclusion
viability
water
Curing
Polymers
drugs

Keywords

  • Biohybrid nanoweb
  • Electrospinning
  • Nanofibers
  • Nanomaterials
  • Vaginal web

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry
  • Chemical Engineering(all)
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Nanofibrous solid dosage form of living bacteria prepared by electrospinning. / Nagy, Zs K.; Wagner, I.; Suhajda, Á; Tobak, T.; Harasztos, A. H.; Vigh, T.; Sóti, P. L.; Pataki, H.; Molnár, K.; Marosi, G.

In: Express Polymer Letters, Vol. 8, No. 5, 05.2014, p. 352-361.

Research output: Contribution to journalArticle

Nagy, ZK, Wagner, I, Suhajda, Á, Tobak, T, Harasztos, AH, Vigh, T, Sóti, PL, Pataki, H, Molnár, K & Marosi, G 2014, 'Nanofibrous solid dosage form of living bacteria prepared by electrospinning', Express Polymer Letters, vol. 8, no. 5, pp. 352-361. https://doi.org/10.3144/expresspolymlett.2014.39
Nagy, Zs K. ; Wagner, I. ; Suhajda, Á ; Tobak, T. ; Harasztos, A. H. ; Vigh, T. ; Sóti, P. L. ; Pataki, H. ; Molnár, K. ; Marosi, G. / Nanofibrous solid dosage form of living bacteria prepared by electrospinning. In: Express Polymer Letters. 2014 ; Vol. 8, No. 5. pp. 352-361.
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