Nanoencapsulation of antitubercular drug isoniazid and its lipopeptide conjugate

E. Kiss, K. Pribranska, K. Hill, Cs B. Penzes, K. Horvati

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Isoniazid (INH) is a first line drug for treatment of the widespread deadly disease caused by Mycobacterium tuberculosis. Peptide conjugate of INH was designed and synthesised for targeted and receptor mediated cellular uptake of INH. Chemical composition, hydrophobicity (n-octanol/water partition coefficient), and membrane affinity (using a Langmuir lipid monolayer as a model system) of the conjugate were characterised. Hydrophilicity of the drug was remarkably decreased by the conjugation which resulted in improved interaction with lipid layer and allowed its efficient encapsulation into polylactic/glycolic acid nanoparticles enhancing the bioavailability of the drug.

Original languageEnglish
Pages (from-to)1728-1734
Number of pages7
JournalJournal of Dispersion Science and Technology
Volume32
Issue number12
DOIs
Publication statusPublished - 2011

Fingerprint

Antitubercular Agents
Lipopeptides
Isoniazid
Lipids
drugs
glycolic acid
lipids
Hydrophilicity
Hydrophobicity
Encapsulation
Pharmaceutical Preparations
1-Octanol
Peptides
tuberculosis
bioavailability
Monolayers
hydrophobicity
Nanoparticles
Membranes
conjugation

Keywords

  • Antituberculotic drug conjugate
  • Drug encapsulation
  • Membrane affinity
  • Nanoprecipitation
  • Plga nanoparticles

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Surfaces, Coatings and Films

Cite this

Nanoencapsulation of antitubercular drug isoniazid and its lipopeptide conjugate. / Kiss, E.; Pribranska, K.; Hill, K.; Penzes, Cs B.; Horvati, K.

In: Journal of Dispersion Science and Technology, Vol. 32, No. 12, 2011, p. 1728-1734.

Research output: Contribution to journalArticle

Kiss, E. ; Pribranska, K. ; Hill, K. ; Penzes, Cs B. ; Horvati, K. / Nanoencapsulation of antitubercular drug isoniazid and its lipopeptide conjugate. In: Journal of Dispersion Science and Technology. 2011 ; Vol. 32, No. 12. pp. 1728-1734.
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