Nanoencapsulated and microencapsulated enzymes in drug antidotal therapy

Mária Szilasi, Marianna Budai, Lívia Budai, Ilona Petrikovics

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

A catalytic bioscavenger for the therapeutic and prophylactic defense against recognized chemical threat agents has been a long-standing objective of civilian and military research. Among the toxic agents, organophosphate molecules and cyanide have been widely studied. In order to overcome the limitations of traditional antidotal therapies, isolated, purified, recombinant enzymes with bacterial origin possessing fast catalytic activity were used in in vitro and in vivo experiments. However, the fast degradation, excretion and adverse immunologic reaction against enzymes limit their in vivo use. Development of biodegradable, nontoxic carrier systems, microparticles, and nanoparticles - offering advantageous pharmacokinetic parameters was suggested. Present work deals with the perspectives of carrier systems, such as resealed and annealed erythrocytes and sterically stabilized liposomes. Dendritic polymers and polymer-conjugated enzymes, being in the focus of extensive research efforts nowadays, are also discussed.

Original languageEnglish
Pages (from-to)522-531
Number of pages10
JournalToxicology and Industrial Health
Volume28
Issue number6
DOIs
Publication statusPublished - Jul 1 2012

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Keywords

  • Organophosphate
  • antagonism
  • antidotal enzyme
  • cyanide
  • dendrimer
  • sterically stabilized liposome

ASJC Scopus subject areas

  • Toxicology
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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